Antisense inhibition of human mek1 expression

Details Antisense inhibition of human mek1 expression Antisense inhibition of human mek1 expression

1998-11-20

2000-08-01

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435325, 435366, 435455, 536 231, 536 2431, 536 2433, 536 245, C12Q 168, C12N 1500, C07H 2104

Patent

active

060965436

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of MEK1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEK1. Methods of using these compounds for modulation of MEK1 expression and for treatment of diseases associated with expression of MEK1 are provided.

REFERENCES:
patent: 5736381 (1998-04-01), Davis et al.
patent: 5801154 (1998-09-01), Baracchini et al.
patent: 5804427 (1998-09-01), Davis et al.
Watabe et al. J. Biol. Chem. 271:14067-14073, 1996.
Milner et al. Nature Biotechnology 15:537-541, Jun. 1997.
Branch TIDS 23:45-50, Feb. 1998.
Crooke, Ch1 of "Antisense Research & Application", Springer, New York, 1998, pp. 1-50.

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