Antisense inhibition of human Akt-2 expression

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

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435 6, 435 911, 435325, 435366, 435455, 536 231, 536 243, 536 2431, 536 2433, 536 245, C12Q 168, C12N 1500, C07H 2104

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060430907

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Akt-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Akt-2. Methods of using these compounds for modulation of Akt-2 expression and for treatment of diseases associated with expression of Akt-2 are provided.

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Cheng et al., AKT2, a putative oncogene encoding a member of a subfamily of protein- serine/threonine kinases, is amplified in human ovarian carcinomas, Proc. Natl. Acad. Sci. U S A, 1992, 89:9267-9271.
Cheng et al., Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA, Proc. Natl. Acad. Sci. U S A, 1996, 93:3636-3641.
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