Antisense inhibition of G-alpha-i2 expression

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

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435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1585

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active

060401796

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of G-alpha-i2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G-alpha-i2. Methods of using these compounds for modulation of G-alpha-i2 expression and for treatment of diseases associated with expression of G-alpha-i2 are provided.

REFERENCES:
Hamm, The many faces of G protein signaling, J. Biol. Chem., 1998, 273:669-672.
Lyons, Two G protein oncogenes in human endocrine tumors, Science, 1990, 249:655-659.
Miller, G-protein alpha subunit Gi (alpha) 2 mediates erythropoietin signal transduction in human erythroid precursors, J. Clin, Invest., 1996, 98:1728-1736.
Moxham, Induction of G alpha i2-specific antisense RNA in vivo inhibits neonatal growth, Science, 1993, 260:991-995.
Murga, Activation of Akt/Protein kinase B by G protein-coupled receptors. A role for alpha and betagamma subunits of heterotrimeric g proteins acting through phosphaltidylinositol-3-oh kinasegamma [In Process Citation], J. Biol. Chem., 1998, 273:19080-19085.
Redmond, Flow-mediated regulation of G-protein expression in cocultured vascular smooth muscle and endothelial cells, Arterioscler. Thromb. Vasc. Biol., 1998, 18:75-83.
Rudolph, Ulcerative colitis and adenocarcinoma of the colon in G alpha i2--deficient mice, Nat. Genet., 1995, 10:143-150.
Schmidt, Alterations in guanine nucleotide regulatory protein expression and activity in human hepatocellular carcinoma, Hepatology, 1997, 26:1189-1194.
Svoboda, Cold-induced reduction in Gi alpha proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment, Biochem. J., 1996, 314:761-768.
Ujike, Increased Gi alpha and Go alpha mRNAs in hippocampus after repeated methamphetamine administration, Neuroreport., 1996, 7:2036-2040.
Wang, The Gs alpha/Gi alpha 2 axis controls adipogenesis independently of adenylylcyclase, Int. J. Obes. Relat. Metab. Disord., 1996, 20 Suppl 3:S26-31.
Watkins, Regulation of the differentiation of teratocarcinoma cells into primitive endoderm by G alpha i2, Science, 1992, 258:1373-1375.
Wise, Interactions of the alpha2A-adrenoceptor with multiple Gi-family G--proteins: studies with pertussis toxin-resistant G-protein mutants [published erratum appears in Biochem J May 1, 1997; 323 (Pt 3):864], Biochem. J., 1997, 321:721-728.
Wu, Inhibition of phospholipase C blocks opioid receptor-mediated activation of Gi proteins, Neuroreport., 1998, 9:99-103.

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