Antisense inhibition of G-alpha-16 expression

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 6, 435 911, 435366, 536 231, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 1168, C12N 1585

Patent

active

061070912

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of G-alpha-16. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G-alpha-16. Methods of using these compounds for modulation of G-alpha-16 expression and for treatment of diseases associated with expression of G-alpha-16 are provided.

REFERENCES:
Branch, TIBS 23 pp. 45-50, Feb. 1998.
Flanagan et al., Nature Biotech. 17:48-52, Jan. 1999.
Crooke, Antisense Research and Application, pp. 1-50, 1998.
Baltensperger et al., J. of Biol. Chem. 272(15) pp. 10151-10159, 1997.
Uhlmann et al., Chem. Rev., 90 (4) pp. 543-584, Jun. 1990.
Amatruda, G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells, Proc. Natl. Acad. Sci. U S A, 1991, 88:5587-5591.
Arai, Differential regulation of G-protein-mediated signaling by chemokine receptors, J. Biol. Chem., 1996, 271:21814-21819.
Baltensperger, The P2U purinoceptor obligatorily engages the heterotrimeric G protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells, J. Biol. Chem., 1997, 272:10151-10159.
Giesberts, Subcellular localization of alpha-subunits of trimeric G-proteins in human platelets, Biochem. Biophys. Res. Comun., 1997, 234:439-444.
Hamm, The many faces of G protein signaling, J. Biol. Chem., 1998, 273:669-672.
Higashita, Galpha16 mimics vasoconstrictor action to induce smooth muscle alpha-actin in vascular smooth muscle cells through a Jun-NH2-terminal kinase-dependent pathway, J. Biol. Chem., 1997, 272:25845-25850.
Kozasa, Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits, Proc. Natl. Acad. Sci. U S A, 1993, 90:9176-9180.
Lee, Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C, J. Neurochem., 1998, 70:2203-2211.
Lippert, G alpha16 protein expression is up-and down-regulated following T-cell activation: disruption of this regulation impairs activation-induced cell responses, FEBS Lett., 1997, 417:292-296.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antisense inhibition of G-alpha-16 expression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antisense inhibition of G-alpha-16 expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense inhibition of G-alpha-16 expression will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-579503

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.