Antisense inhibition of focal adhesion kinase expression

Details Antisense inhibition of focal adhesion kinase expression Antisense inhibition of focal adhesion kinase expression

1999-08-19

2000-10-17

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 536 231, 536 245, 514 44, C07H 2104, C12Q 168, C12N 1500

Patent

active

061330310

ABSTRACT:
Compounds, compositions and methods are provided for inhibiting FAK mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding FAK. Methods of using these antisense compounds for inhibition of FAK expression and for treatment of diseases, particularly cancers, associated with overexpression or constitutive activation of FAK are provided.

REFERENCES:
patent: 6015893 (2000-01-01), Cance et al.
Lou, et al., "In Vivo Gene Transfer and Overexpression of Focal Adhesion Kinase (pp125 FAK) Mediated by Recombinant Adenovirus-Induced Tendon Adhesion Formation and Epitenon Cell Change", J. Orthopaedic Res. 1997, 15, 911-918.
Naruse, et al., "Pp125.sup.FAK is required for stretch dependent morphological response of endothelial cells", Oncogene 1998, 17, 445-463.
Shibata, K., et al., "Both Focal Adhesion Kinase and c-Ras Are Required for the Enhanced Matrix Metalloproteinase 9 Secretion by Fibronectin in Ovarian Cancer Cells.sup.1 ", Cancer Res., 1998, 5, 900-903.
Sonoda, et al., "A Suppressive Role of p125FAK Protein Tyrosine Kinase in Hydrogen Peroxide-Induced Apoptosis of T98G Cells", Biochem. Biophys. Res. Comm., 1997, 241, 769-774.
Tanaka et al., "Possible Involvement of Focal Adhesion Kinase, p125.sup.FAK, in Osteoclastic Bone Resorption", J. Cell. Biochem. 1995, 58, 424-435.
Takeuchi, et al., "Differentiation and Transforming Growth Factor-.beta. Receptor Down-regulation by Collagen-.alpha.2.beta.1 Integrin Interaction Is Mediated by Focal Adhesion Kinase and Its Downstream Signals in Murine Osteoblastic Cells", J. Biol. Chem., 1997, 272, 29309-29316.
Xu, et al., "Attenuation of the Expression of the Focal Adhesion Kinase Induces Apoptosis in Tumor Cells.sup.1 ", Cell Growth Diff., 1996, 7, 413-418.

Affiliated with

Also associated with

Rating

Antisense inhibition of focal adhesion kinase expression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antisense inhibition of focal adhesion kinase expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense inhibition of focal adhesion kinase expression will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-467424