Antisense inhibition of Elk-1 expression

Details Antisense inhibition of Elk-1 expression Antisense inhibition of Elk-1 expression

1998-12-17

1999-09-07

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435325, 435366, 536 231, 536 2431, 536 2433, 536 245, C12Q 168, C07H 2104, C12H 1500

Patent

active

059486805

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of ELK-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding ELK-1. Methods of using these compounds for modulation of ELK-1 expression and for treatment of diseases associated with expression of ELK-1 are provided.

REFERENCES:
Dittmer et al., Ets transcription factors and human disease, Biochem. Biophys. Acta, 1998, 1377:F1-11.
Rao et al., elk, tissue -specific ets-related genes on chromosomes X and 14 near translocation breakpoints, Science, 1989, 244:66-70. Process Citation!, Oncogene, 1998, 17:527-532.
Sharrocks et al., The ETS-domain transcriptional factor family, Int. J. Biochem. Cell Biol., 1997, 29:1371-1387.
Weiss et al., MEK inhibition augments Raf activity, but has variable effects on mitogenesis, in vascular smooth muscle cells Am. J. Physiol., 1998, 274:C1521-1529.
Crooke, Ch 1 of "Antisene research & application," Springer, 1998, pp. 1-50.
Brands TIBS 23:45-50, Feb. 1998.
Flanagan et al, nafire Biotechnology 17:48-52, 1999.

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