Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1998-12-03
1999-09-28
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435 911, 435325, 435366, 536 231, 536 2431, 536 2433, 536245, C12Q 168, C07H 2104, C12N 1500
Patent
active
059587725
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of Cellular Inhibitor of Apoptosis-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Cellular Inhibitor of Apoptosis-1. Methods of using these compounds for modulation of Cellular Inhibitor of Apoptosis-1 expression and for treatment of diseases associated with expression of Cellular Inhibitor of Apoptosis-1 are provided.
REFERENCES:
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Li et al., Expression of inhibitor of apoptosis proteins (IAPs) in rat granulosa cells during ovarian follicular development and atresia, Endocrinology, 1998, 139:1321-1328.
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Roy et al., The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases, Embo J., 1997, 16:6914-6925.
Shu et al., The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex, Proc. Natl. Acad. Sci. U S A, 1996, 93:13973-13978.
Thompson, Apoptosis in the pathogenesis and treatment of disease, Science, 1995, 267:1456-1462.
Uren et al., Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors, Proc. Natl. Acad. Sci. U S A, 1996, 93:4974-4978.
Wang et al., NF-kappaB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation, Science, 1998, 281:1680-1683.
Branch TIBS 23:45-50, Feb. 1998.
Crooke, S.T. In "Antisense Research & Application", Ch1, pp. 1-50, Springer, 1998.
Ackermann Elizabeth J.
Bennett C. Frank
Cowsert Lex M.
Isis Pharmaceuticals , Inc.
LeGuyader John L.
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