Chemistry: molecular biology and microbiology – Vector – per se
Patent
1996-03-11
1998-12-01
Elliot, George C.
Chemistry: molecular biology and microbiology
Vector, per se
435 911, 536 241, 536 245, C12N 1500, C07H 2102, C07H 2104, C12P 1934
Patent
active
058437703
ABSTRACT:
Antisense constructs ditrected against viral cis-acting post-transcriptional regulatory sequences ("PREs") are disclosed. In one embodiment, the antisense construct is an expression plasmid encoding one or more antisense transcripts which hybridize under intracellular conditions to all or a portion of a viral PRE within a viral transcript, the PRE having the function of directing export of the viral transcript from the nucleus to the cytoplasm of a cell. The antisense constructs can be used to inhibit viral production, such as HBV production.
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Gonzales Jose E. N.
Ill Charles R.
Elliot George C.
McGarry Sean
Remillard, Esq. Jane E.
The Immune Response Corporation
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