Antisense composition and method for treatment of CMV infection

Details Antisense composition and method for treatment of CMV infection Antisense composition and method for treatment of CMV infection

1997-01-17

1998-06-16

LeGuyader, John L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 6, 435 911, 4351723, 536 231, 536 243, 536 245, A61K 4800, C07H 2104, C12Q 168

Patent

active

057671028

ABSTRACT:
This invention concerns compositions and methods for the treatment of CMV infections. A composition including an antisense oligonucleotide targeted to the IE2 gene of CMV and a pharmaceutically acceptable carrier were used stop progression in CMV retinitis.

REFERENCES:
patent: 4689320 (1987-08-01), Kaji
patent: 5034506 (1991-07-01), Summerton et al.
Gewirtz et al. PNAS. 93:3161-3163 (1996).
Rojanasakul Adv. Asug. Dil. Reviews 18:115-131 (1996).
Gennaro, Alfonso, Ed., Remington's Pharmaceutical Sciences, 18th Edition 1990. Mack Publishing Co., Easton, PA.
P.E. Nielsen, M. Egholm, R.H. Berg, O. Buchardt, "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide", Science 1991, 254, 1497.

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