Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1979-05-07
1980-12-30
Sutto, Anton H.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548133, C07D27106, A61K 3142
Patent
active
042423511
ABSTRACT:
The invention relates to oxadiazole derivatives which are histamine H-2 antagonists and which inhibit the secretion of gastric acid, to methods for their manufacture and to pharmaceutical compositions containing them. The oxadiazole derivatives are of the formula: ##STR1## in which Y is O, S, CH.sub.2 or a direct bond; m is 0 to 4 and n is 1 to 4, provided that when Y is S or O m is 1 to 4 and when Y is O n is 2 to 4; A is a 3,4-dioxocyclobuten-1,2-diyl radical or C=Z in which Z is O, S, NCN, NNO.sub.2, CHNO.sub.2, NCONH.sub.2, C(CN).sub.2, NCOR.sup.1, NCO.sub.2 R.sup.1, NSO.sub.2 R.sup.1 or NR.sup.2 in which R.sup.1 is alkyl or aryl and R.sup.2 is H or alkyl; B is alkoxy or alkylthio or NHR.sup.3 in which R.sup.3 is H or alkyl: and the salts thereof.
REFERENCES:
patent: 3687971 (1972-08-01), Shen et al.
patent: 4163048 (1979-07-01), Ross et al.
Mant Derrick M.
Yellin Tobias O.
ICI Americas Inc.
Imperial Chemical Industries Limited
Sutto Anton H.
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