Antisecretory heterocyclic derivatives, process for their manufa

Details Antisecretory heterocyclic derivatives, process for their manufa Antisecretory heterocyclic derivatives, process for their manufa

1979-10-10

1983-02-22

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424246, 424249, 424263, 544 8, 544182, 544320, 544321, 546256, 546275, 546276, 546277, A61K 31505, C07D41712

Patent

active

043748368

ABSTRACT:
The invention relates to a heterocyclic derivative of the formula: ##STR1## where D is O, S or NH; E is CH or when D is O or S, E is N; Y is S, O, CH.sub.2, SO or a direct bond; m is 0 to 4 and n is 1 to 4, provided that when Y is S, O or SO m is 1 to 4, when Y is O or SO, n is 2 to 4; A is C.sub.(3-4) chain comprising at least one C and also optionally S, N, 2N or N and S, and also comprising C.dbd.O or C.dbd.S or where possible SO.sub.2, the chain optionally substituted by 1 or 2 C.sub.(1-6) alkyl, benzyl, naphthylmethyl, 2-phenethyl, 4-phenylbutyl, pyridylmethyl, thiazolylmethyl, thienylmethyl, benzyloxy, pyridylmethoxy or phenoxymethyl radicals each optionally substituted on the aromatic ring system by 1 to 3 halogen atoms or methyl, methoxy, trifluoromethyl, dimethylamino, phenyl or phenoxy radicals; and the salts thereof.

REFERENCES:
patent: 3932644 (1976-01-01), Durant et al.
patent: 4154834 (1979-05-01), Brown et al.
patent: 4185103 (1980-01-01), Brown et al.
patent: 4216318 (1980-08-01), Brown et al.
patent: 4218452 (1980-08-01), Brown et al.

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