Antisecretory guanidine derivatives and pharmaceutical compositi

Details Antisecretory guanidine derivatives and pharmaceutical compositi Antisecretory guanidine derivatives and pharmaceutical compositi

1979-01-18

1982-02-09

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424263, 424269, 424270, 424272, 424273R, 548143, 548193, 548233, C07D27720

Patent

active

043150098

ABSTRACT:
The guanidine derivative has the formula: ##STR1## where X is O or S: Y is N, CH or CCH.sub.3 : m is 0 or 1: R.sup.1 is hydrogen and R.sup.2 cyano, trifluoroacetyl, C.sub.1-6 alkanoyl, 4,5-dihydro-4-oxothiazol-2-yl or A-B where A is 3,4-dioxocyclobutene-1,2-diyl or C.dbd.Z where Z is oxygen, sulphur, NCN, NNO.sub.2, CHNO.sub.2, NCONH.sub.2, C(CN).sub.2, NCOR.sup.6, NCO.sub.2 R.sup.6, NSO.sub.2 R.sup.6 or NR.sup.7 where R.sup.6 is C.sub.1-6 alkyl and R.sup.7 is hydrogen or C.sub.1-6 alkyl and B is C.sub.1-6 alkyl, alkoxy or alkylthio or NR.sup.8 R.sup.9 where R.sup.8 and R.sup.9 are hydrogen, C.sub.1-10 alkyl, C.sub.3-10 -alkenyl, alkynyl or alkoxyalkyl, C.sub.2-6 (primary hydroxy)alkyl, or, when R.sup.9 is hydrogen, R.sup.8 is 2-[[5-dimethylaminomethylfuran-2-yl]methylthio]-ethylamino or R.sup.8 and R.sup.9 are together a 5- or 6-membered non-aromatic ring optionally containing an additional N or O; or R.sup.1 and R.sup.2 are together imidazolidin-2-ylidene: R.sup.3 is hydrogen or fluorine: R.sup.4 is halogen or methyl: R.sup.5 is hydrogen, C.sub.1-6 alkyl or C.sub.3-10 alkoxyalkyl: and the salts thereof.

REFERENCES:
patent: 4088769 (1978-05-01), Black et al.
patent: 4089965 (1978-05-01), Angier et al.
patent: 4154844 (1979-05-01), Durant et al.
patent: 4160030 (1979-07-01), Durant et al.
patent: 4165378 (1979-04-01), Gilman et al.

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