Antisecretory agents derived from meldrum's acid

Details Antisecretory agents derived from meldrum's acid Antisecretory agents derived from meldrum's acid

1983-10-20

1985-10-15

Siegel, Alan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514444, 514452, 549 50, 549 60, 549274, 548335, A61K 3138, A61K 3140, C07D23354

Patent

active

045475164

ABSTRACT:
Disclosed herein are antisecretory agents represented by the formula ##STR1## wherein R.sup.1 is hydrogen and R.sup.2 is lower alkylthio, (2-thienylmethyl)thio or SCH.sub.2 -- COOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl, or R.sup.1 and R.sup.2 are independently a lower alkylthio or (2-thienylmethyl)thio, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a 2-imidazolidinylidene; and R.sup.3 and R.sup.4 are each the same lower alkyl, or R.sup.3 and R.sup.4 together with the carbon atoms to which they are attached form a cyclohexane wherein said carbon atom is a spiro atom in common with the cyclohexane ring and the adjoining dioxane ring.

REFERENCES:
patent: 4118557 (1978-10-01), Lesher
U. Herzog and H. Reinshagen, Eur. J. Med. Chem.-Chim. Ther., 11 415 (1976).
F. P. Colona et al., J. Chem. Soc., Perkin Trans., 2, 279 (1978).
J. Sandstrom and U. Sjostrand, Tetrahedron, 34, 371 (1978).
U. Sjostrand and J. Sandstrom, Tetrahedron, 34, 3305 (1978).
J.-P. Celerier et al., J. Org. Chem., 44, 3089 (1979).
J.-P. Celerier et al., Synthesis, 2, 130 (1981).
J.-P. Celerier et al., Tetrahedron Letters, 22, 963 (1981).

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