Antisecretory agents

Details Antisecretory agents Antisecretory agents

1980-03-10

1981-09-15

Randolph, John D.

Harness for working animal

546286, 546300, 546332, 424263, C07D21328

Patent

active

042898765

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R.sup.2 is hydrogen, hydroxy, cyano, (lower)alkyl, (lower)alkoxy, halogen or amino; n is 2 or 3; X is NR.sup.3 or CHR.sup.3 ; R.sup.3 is cyano, nitro, SO.sub.2 Ar; or SO.sub.2 (lower)alkyl; R.sup.12 is hydrogen or (CH.sub.2).sub.p NR.sup.13 R.sup.14 ; p is an integer of from 1 to 4, inclusive; R.sup.13 and R.sup.14 each are independently hydrogen or (lower)alkyl; and Ar is phenyl or phenyl containing 1 or 2 substituents independently selected from halogen and (lower)alkyl; and nontoxic, pharmaceutically acceptable salts thereof, are potent anti-ulcer agents.

REFERENCES:
patent: 3971786 (1976-07-01), Durant et al.
patent: 4060621 (1977-11-01), Durant et al.
patent: 4129657 (1978-12-01), Durant et al.

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