Antisecretory 16,16-dimethyl-17-oxaprostaglandins

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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260556A, 260556AC, 260557R, 260558R, 260561R, 424321, 424324, C07C10319, C07C14375, A61K 3116, A61K 3118

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active

041698959

ABSTRACT:
N-alkylsulfonyl, N-alkanoyl and N-benzoyl 16,16-dimethyl-17-oxaprostaglandin E.sub.2 and E.sub.1 carboxamides having antisecretory biological activity as well as intermediates for their synthesis are disclosed.

REFERENCES:
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patent: 3927197 (1975-12-01), Monkhouse
patent: 3954741 (1976-05-01), Schaaf et al.
patent: 3981868 (1976-09-01), Bernady et al.
patent: 4060534 (1977-11-01), Bundy
patent: 4061671 (1977-12-01), Beck et al.
patent: 4098805 (1978-07-01), Bundy
patent: 4130584 (1978-12-01), Bundy
Collins et al., ". . . . Prostaglandins," Tetrahedron Letters, No. 48, pp. 4217-4220, 1975.

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