Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1993-07-29
1995-11-28
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424423, 424443, 424449, 424451, 424464, 514 62, 536 553, 528354, 528361, 273274, A61K 3722, A61K 948, A61K 31715, C07H 506
Patent
active
054705789
ABSTRACT:
This invention provides an antirheumatic composition which comprises a lipid-bound glycosaminoglycan or a salt thereof as an active ingredient and a pharmaceutically acceptable carrier and has an effect to inhibit extension of pannus.
REFERENCES:
Annals of the Rheumatic Disease, vol. 42, No. 3, Jun. 1983, pp. 254-263, Shiozawa, S. et al Immunoelectron Microscopic Demonstration of Fibronectinin Rheumuatiod Pannus and at the Cartilage-Pannus and at the Cartilage-Pannus Junction.
The Journal of Biological Chemistry, vol. 264, No. 14, May 15, 1989, pp. 8012-8018, Yamagata, M. et al, Regulation of Cell-Substrate Adhesion by Proteoglycans Immobilized on Extracellular Substrates.
Journal of Cell Science, vol. 100, No. 2, Oct. 1991, pp. 387-395, Tsukahara, T. et al, Enhanced Expression of Fibronectin by CMD/CMD Chondrocytes and its Modulation by Exogenously added Proteoglycan.
S. Shiozawa and K. Shiozawa, Scand. J. Rheumatology, Suppl., 74, 65-72 (1988).
S. Aoki et al, Arthritis and Rheumatism, 28(5), 522-528 (1985).
S. Aoki, Chubu Rheum. Assoc., 21(1), 1-13 (1990).
S. Shiozawa et al, Annals of the Rheumatic Diseases, 51, 869-873 (1992).
R. K. Strachan et al, Annals of the Rhumatic Diseases, 49, 949-951 (1990).
N. J. Zvaifler, Adv. Immunol., 16, 265-336 (1973).
Seikagaku, 62(7), 1990).
Seikagaku, 63(8), 948 (1991).
Aoki Shigehisa
Iwasaki Shinichi
Kimata Koji
Sugiura Nobuo
Suzuki Sakaru
Azpuru Carlos A.
Seikagaku Kogyo Kabushiki Kaisha
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