Antirheumatic composition

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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424423, 424443, 424449, 424451, 424464, 514 62, 536 553, 528354, 528361, 273274, A61K 3722, A61K 948, A61K 31715, C07H 506

Patent

active

054705789

ABSTRACT:
This invention provides an antirheumatic composition which comprises a lipid-bound glycosaminoglycan or a salt thereof as an active ingredient and a pharmaceutically acceptable carrier and has an effect to inhibit extension of pannus.

REFERENCES:
Annals of the Rheumatic Disease, vol. 42, No. 3, Jun. 1983, pp. 254-263, Shiozawa, S. et al Immunoelectron Microscopic Demonstration of Fibronectinin Rheumuatiod Pannus and at the Cartilage-Pannus and at the Cartilage-Pannus Junction.
The Journal of Biological Chemistry, vol. 264, No. 14, May 15, 1989, pp. 8012-8018, Yamagata, M. et al, Regulation of Cell-Substrate Adhesion by Proteoglycans Immobilized on Extracellular Substrates.
Journal of Cell Science, vol. 100, No. 2, Oct. 1991, pp. 387-395, Tsukahara, T. et al, Enhanced Expression of Fibronectin by CMD/CMD Chondrocytes and its Modulation by Exogenously added Proteoglycan.
S. Shiozawa and K. Shiozawa, Scand. J. Rheumatology, Suppl., 74, 65-72 (1988).
S. Aoki et al, Arthritis and Rheumatism, 28(5), 522-528 (1985).
S. Aoki, Chubu Rheum. Assoc., 21(1), 1-13 (1990).
S. Shiozawa et al, Annals of the Rheumatic Diseases, 51, 869-873 (1992).
R. K. Strachan et al, Annals of the Rhumatic Diseases, 49, 949-951 (1990).
N. J. Zvaifler, Adv. Immunol., 16, 265-336 (1973).
Seikagaku, 62(7), 1990).
Seikagaku, 63(8), 948 (1991).

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