Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-04-04
1998-05-19
Grumbling, Matthew V.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142278, 5142378, 514614, 514615, 514579, 544 59, 544 60, 544162, 544168, 544164, 544169, 564 1, 564152, 564153, 564154, 564155, 564166, 564162, 564163, 564185, 564190, 564191, 564192, 564193, 564194, 564202, 564217, 564218, 564123, 546152, 546176, 546229, 546336, 548507, A61K 3154, A61K 31535, C07D40304, C07D40314
Patent
active
057536520
ABSTRACT:
The invention relates to compounds of formula ##STR1## and salts, pharmaceutical compositions, intermediates and processes of preparation thereof.
REFERENCES:
patent: 3669967 (1972-06-01), Boltze
patent: 4207338 (1980-06-01), Eckhardt et al.
patent: 4556654 (1985-12-01), Showalter et al.
patent: 5409927 (1995-04-01), Bold et al.
Derwent Abstract 94-286706/36 (Corresponding to WO/ 94/ 21604.
Derwent Abstract 94-286705/36 (Corresponding to DE 43 08 095).
Derwent Abstract 94,893p--1967; "Hydrazine Derivatives as additives to Photographic Developers".
Streicher et al; Synthese Eines Tzaanalogen Des Antibiotikums Negamycin Chem Ber vol. 108, (1975) 813-819.
Chem Abstr, 82 124,685g (1975).
Ruprecht etal; "Development of Antiviral Treatment Strategies in Murine Models"; AIDS Research and Human Retroviruses 8(6) 1992 pp. 997-1011.
Yarchoan, et al; The Immunology of HIV Infection. Implications for Therapy; AIDS Research and Human Retroviruses 8(6) 1992 pp. 1023-1031.
Harada et al; Infection of HTLV-III/LAV in HTLV-I Carrying Cells MT-2 and MT-4 and Application in a Plague Assay; Science 229, p. 563-566, 1985.
Richards et al.; Sensitive, Soluble Chromogenic Substrates for HIV-I Proteinase; The Journal of Biological Chemistry, 265, p. 7733-7736 (1990).
Billch et al; Synthetic Peptides as Subtrates and Inhibitors of Human Immune Deficiency Virus-I Protease; The Journal of Biological Chemistry; 268, p. 17905-17908 (1988).
Schneider et al; Enzymatic Activity of a Synthetic 99 Residue Protein Corresponding to the Putative HIV-I Protease; Cell, 54, p. 363-368 (1988).
Ciba Geigy Internal Publication Abstract of Roche Protease Inh Mentioning Brit J. Clin. Pharmacol. 34, 155-156 P; Williams et al.
Shaw et al; Brit. J. Clin. Pharmacol., 34, p. 166P-167P (1992).
Murihead et al; Brit J. Clin Pharmacol. 34, 170P-171P (1992).
Srimal et al; Indram J. Exp. Biol. 19(11), p. 1069 (1964).
Evans et al; J. Org. Chem. 50, 4615 (1985).
Chem Abstr. 62:1249 (1965) Corresponding to FR 1,355,993.
Derwent Abstract 92-016792/03 Corresponding to DD 292,980 (See P.I, Item "AO").
Wlodawer et al; Science 245, 616 (1989). "Conserved Folding in Retroviral Proteases: Crystal Structure of a Synthetic, HIV-I Prostease".
Sham et al; J. Chem Soc., Chem. Commun. 1993, 1052-3(1993). "Facile Sythesis of Potent HIV-I Protease Inhibitors Containing a Novel Pseude-symmetric Dipeptide Isostere".
Harada et al. Infection of HTLV-III/LAV in HTLV-I-Carrying Cells MT-2 and MT-4 and Application in a Plaque Assay, Science, 229 p. 563-566 (1985).
Basler Zeitung, Wednesday, Jun. 16, 1993, Nr. 137, Tell IV, p. 39.
Richards et al. Sensitive, Soluble Chromogeni Substrates for HIV-I Proteinase, The Journa of Biological Chemistry, 265, p. 7733-7736 (1990).
Billich et al. Synthetic Peptides as Substrat and Inhibitors of Human Immune Deficiency Virus-I Protease, The Journal of Biologoical Chemistry, 268, p. 17905-17908 (1988).
Schneider et al. Enzymatic Activity of a Synthetic 99 Residue Protein Corresponding to the Putative HIV-I Protease, Cell, 54, p. 363-368 (1988).
Ciba-Geigy Internal Publication Abstract of Williams et al. Brit. J. Clin. Pharmacol. 34, 155P-156P; Shaw et al., Brit. J. Clin. Pharmacol., 34, p. 170P-171P (1992).
94,893p--"Hydrazine Derivatives as Additives to Photographic Developers" (1967).
W.Streicher et al "Synthese Eines Azaanalogen Des Antibiotkums Negaylin".
Chem. Ber. vol. 108, (1975) pp. 813-819 and Chem. Abst. 82:124685q (1975) as Translation thereof.
Roberts et al., Science (1990) vol. 248, 358-361.
Bhagwat Shripad
Bold Guido
Fassler Alexander
Lang Marc
Schneider Peter
Ferraro Gregory D.
Grumbling Matthew V.
Novartis Corporation
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