Antipsychotic tetrahydropyridinyl-indoles, compositions and meth

Details Antipsychotic tetrahydropyridinyl-indoles, compositions and meth Antipsychotic tetrahydropyridinyl-indoles, compositions and meth

1980-06-30

1982-04-13

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546273, A61K 3144, C07D40104

Patent

active

043247903

ABSTRACT:
Novel tetranydro-pyridinyl-indoles of the formula ##STR1## wherein X is selected from the group consisting of alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 5 carbon atoms, alkynyl of 3 to 5 carbon atoms, cycloalkyl of 5 to 6 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, aralkyl of 7 to 12 carbon atoms, hydroxyalkyl of 2 to 5 carbon atoms and phenoxyalkyl of 1 to 5 alkyl carbon atoms, R is selected from the group consisting of hydrogen, halogen, alkoxy of 1 to 3 carbon atoms, nitro, amino, trifluoromethyl and methylthio, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms with the proviso that if R is hydrogen, halogen or alkoxy of 1 to 3 carbon atoms, X must be hydroxyalkyl or phenoxyalkyl and their non-toxic, pharmaceutically acceptable acid addition salts having neuroleptic, antipsychotic and antiemetic activity and their preparation.

REFERENCES:
patent: 3850938 (1974-11-01), Derible et al.
patent: 3980658 (1976-09-01), Possanza et al.
patent: 3993764 (1976-11-01), Dumont et al.
patent: 4196209 (1980-04-01), Dumont et al.
patent: 4232031 (1980-11-01), Dumont et al.
Freter, J. Org. Chem., 1975, vol. 40 (7), pp. 2525-2529.

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