Antipsychotic fused-ring pyridinylpiperazine derivatives

Details Antipsychotic fused-ring pyridinylpiperazine derivatives Antipsychotic fused-ring pyridinylpiperazine derivatives

1986-07-16

1987-06-30

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514231, 514234, 514255, 544 582, 544121, 544230, 544362, A61K 31495, C07D23704

Patent

active

046771042

ABSTRACT:
Disubstituted 1,4-piperazinyl derivatives are disclosed wherein one substituent is a bicyclic fused-ring furo-, pyrrolo-, cyclopentadieno-, or thieno-pyridine heterocyclic system and the second substituent is an alkylene chain attached to cyclic imide heterocycles, such as azaspiro[4.5]decanediones, dialkylglutarimides, thiazolidinediones, succinimides, and morpholine-2,6-diones; or a benzylic carbinol moiety. These compounds have potent antipsychotic and serotonin antagonist activities. 4-[4-[4-(4-Furo[3,2-c]pyridinyl)-1-piperazinyl]butyl]-3,5-morpholinedione is an example of a typical embodiment having selective antipsychotic activity.

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