Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-

Details Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1- Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-

1985-01-16

1986-10-28

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514253, 544230, 544364, 544121, 544 582, A61K 31495, C07D41714, C07D51310

Patent

active

046199306

ABSTRACT:
Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is a substituted pyridin-2-yl ring and the second substituent is a butylene chain attached to cyclic imide heterocycles such as azaspiro[4.5]decanedione, dialkylglutarimide, thiazolidinedione, spirocyclopentylthiazolidinedione, or morpholine-2,6-dione. The compounds have psychotropic properties and 2-[4-[4-(2,4-dioxo-1-thia-3-azaspiro[4.5]nonane-3-yl)butyl]-1-piperazinyl] pyridine-3-carboxaldehyde is a typical embodiment having selective antipsychotic activity.

REFERENCES:
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patent: 3907801 (1975-09-01), Wu et al.
patent: 4305944 (1981-12-01), Temple, Jr. et al.
patent: 4361565 (1982-11-01), Temple, Jr. et al.
patent: 4367335 (1983-01-01), Temple, Jr. et al.
patent: 4456756 (1984-06-01), Temple, Jr. et al.
Wu et al., J. Med. Chem., 15, 447-479 (1972).

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