Antipsychotic cyclic imide derivatives of 2-(4-butylipiperazin-1

Details Antipsychotic cyclic imide derivatives of 2-(4-butylipiperazin-1 Antipsychotic cyclic imide derivatives of 2-(4-butylipiperazin-1

1986-09-30

1988-07-12

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544364, A61K 31495, C07D40114

Patent

active

047570733

ABSTRACT:
Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is a substituted pyridin-2-yl ring and the second substituent is a butylene chain attached to cyclic imide heterocycles such as azaspiro[4.5]decanedione, dialkylglutarimide, thiazolidinedione, spirocyclopentylthiazolidinedione, or morpholine-2,6-dione. The compounds have psychotropic properties and 2-[4-[4-(2,4-dioxo-1-thia-3-azaspiro[4.5]nonane-3-yl)butyl]-1-piperazinyl] -pyridine-3-carboxaldehyde is a typical embodiment having selective antipsychotic activity.

REFERENCES:
patent: 4361565 (1982-11-01), Temple, Jr. et al.
patent: 4524206 (1985-06-01), New et al.

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