Antipsychotic agents, compositions and method of use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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540575, C07D40304, C07D41304, A61K 3155

Patent

active

056961138

ABSTRACT:
This invention relates to compounds of the formula ##STR1## wherein X, Y, Z, m, n and p are as defined within, pharmaceutical compositions containing these compounds and to their use as antipsychotic agents, particularly in the treatment of schizophrenia. Depot derivatives of the compounds are useful for providing long acting effects of the compounds.

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J.P. Yevich et al. J. Med. Chem. 29, pp. 359-369 (1986).
Yevich et al., Synthesis and Biological Evaluation of 1-(1,2-Benzisothiazol-3-yl)-and (1,2-Benzisoxazol-3-yl)piperazine Derivatives as Potential Antipsychotic Agents, J. Med. Chem., 29, pp. 359-369, 1986.

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