Antipsychotic 1-cycloalkylpiperidines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514306, 514314, 514317, 514318, 514323, 514326, 514415, 514419, 544335, 546174, 546176, 546210, 546201, 546194, 546225, 546216, 546236, 546230, 546276, 546147, 546140, 546146, 546223, 546148, 546159, 546150, 546153, 546143, 546163, 546141, 546165, 548254, A61K 31505, C07D23926

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active

051090023

ABSTRACT:
There are provided cycloalkyl piperidine compounds which are useful in the treatment of physiological or drug-induced psychosis or dyskinesia in a mammal. These novel compounds are selective sigma receptor antagonists and have a low potential for movement disorder side effects associated with typical antipsychotic agents.

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CA 95: 24830h, Eistetter et al. (1981).
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CA 96: 123074s, Trijzelaar et al. 1982.
Nagai et al. (1977) Chem. Pharm. Bull. 25: 1911-1922 (1977).

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