Antipsychotic

Details Antipsychotic Antipsychotic

1993-08-25

2001-10-23

Travers, Russell (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

Reexamination Certificate

active

06306907

ABSTRACT:

This application claims foreign priority of JP 227510/1992, filed Aug. 26, 1992.
BACKGROUND OF THE INVENTION
The present invention relates to an antipsychotic.
Psychosis is a mental disease characterized by, for example, schizophrenia and its symptoms can be classified into two types, positive symptoms such as hallucinations, delusions, and abnormal behaviors and negative symptoms such as catatonia, autism, and non-emphasis. Chlorpromazine phenothiazine derivative produced in 1952 was the first antipsychotic to be developed. Haloperidol developed in 1963 is one of the most representative antipsychotics. However, these antipsychotics mainly function to improve positive symptoms caused by blockage of dopamine receptors but are ineffective in improving negative symptoms which are believed to be basic to the schizophrenia pattern. In addition, phencyclidine, an arylcyclohexyl amine derivative, is frequently being abused today by drug users in America and the resulting rapid increase in the number of patients showing schizophrenia-like symptoms has become a social problem. Since such patients show not only positive symptoms of schizophrenia but also its negative symptoms, there is a need for a drug which can improve not only positive symptoms of schizophrenia but also its negative symptoms and which causes no side effect.
SUMMARY OF THE INVENTION
Accordingly, an object of the present invention is to provide an antipsychotic which is effective in treating or preventing psychosis and which causes few or no side effects.


REFERENCES:
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patent: 5120760 (1992-06-01), Horrobin
patent: 5260067 (1993-11-01), Zheng
HCAPLUS abstract, AN 1989:457336, VanRollins, M. et al., J. Lipid. Res. (1989), 30(2), pp. 275-286.*
Goodman Gilman, A. et al., “The Pharmacological Basis of Therapeutics” (6thEd.), Macmillan Pub. Co., New York, (1980), p. 12.*
HCAPLUS abstract, AN 1984: 419194, VanRollins, M. et al., J. Biol. Chem. (1984), 259(9), pp. 5776-5783.*
Chemical Abstracts 113: 158684, Horrobin, (1989).*
Chemical Abstracts 112: 191978, Kimura et al., (1989).*
Chemical Abstracts 119: 125193 (1991), Nishikawa et al.*
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Goodman Gilman et al. (Eds.), The Pharmacological Basis of Therapeutics, 6thEd., Macmillan Pub. Co., New York, 1980, pp. 14-15 and 670-671.

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