Antipsoriatic compositions, method of making, and method of usin

Details Antipsoriatic compositions, method of making, and method of usin Antipsoriatic compositions, method of making, and method of usin

1996-03-22

1999-09-21

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514685, 514863, A61K 3578

Patent

active

059550813

ABSTRACT:
A psoriasis treatment composition derived from the plant Asphodelus Microcarpus includes 3-methylanthralin, chrysophanol, aloe-emodin, aloe-emodin monoacetate, and/or derivatives thereof. The composition is prepared by extracting a liquid from the Asphodelus Microcarpus root and mixing the liquid with acetic acid. A method of treatment includes applying the composition to an affected area of skin at a frequency sufficient to effect an alleviation of symptoms, typically once per day for 14-56 days.

REFERENCES:
patent: 3881000 (1975-04-01), Freidmann et al.
patent: 5091181 (1992-02-01), Papadakis et al.
F. M. Hammouda, et al., Anthraquinones of Certain Egyptian Asphodelus Species. Z. Naturforsch. 29c 351-354, 1974.
"Therapeutic Botanicol Protocal for Psoriasis", Richard Scalzo, Helen Batchelder, Dr. Xiping Wang, and Dr. Jay Glaser, Protocol Journal of Botanical Medicines, Autumn 1994, pp. 1-38.
"Forestomach Papillomas in Flaky Skin and Steel-Dickie Mutant Mice", John P. SUndberg, George A. Kenty, Wesley G. Beamer and Daniel L. Adkinson, J Vet Diagn Invest 4:312-317 (1992), From The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, Received for publication Oct. 7, 1991.
"Epidermal Dendritic Cell Populations in the Flaky Skin Mutant Mouse", John P. Sundberg, Dawnalyn Boggess, Beth A. Sundberg, Wesley G. Beamer and Leonard D. Shultz, Immunol Invest 22:389-401 (1993), Abstract From The Jackson Laboratory, 600 Main St, Bar Harbor , ME 04609.
"Antipsoriatic Anthrones with Modulated Redox Properties", K. Muller, P. Leukel, K. Zieris and I. Gawlik, J Med Chem 37(11):1660-9 (May 27, 1994), Abstract from the Universitate Regensburt, Institut fur Pharmazie, Germany .

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