Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2005-03-29
2005-03-29
Qazi, Sabiha (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
C514S169000, C514S510000, C514S515000, C530S317000, C530S318000
Reexamination Certificate
active
06872713
ABSTRACT:
Saponins of formula (I), a stereoisomeric form thereof or a pharmaceutically acceptable addition salt thereof, wherein R1to R12have the meaning given in the description, can be isolated from plants of the family Myrsinaceae and used, to decrease the infectiousness of and reduce the mortality associated with protozoan parasites of the genus Leishmania which are responsible for a group of conditions known as leishmaniases.
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Apers, S. et al., “Separation of a triterpenoid saponin mixture from Maesa lanceolata: semipreparative reversed-phase wide pore high performance liquid chromatography with temperature control”,Journal of Pharmaceurical and Biomedical Analysis, 1998, 18:4,5, 737-743.
El-On, J. et al., Topical Treatment of New and Old World cutaneous leishmaniasis in experimental animals,Trans. Roy. Soc. Trop. Med. Hyg., 1987, 81, 734-737.
Sindambiwe, J. et al., “Evaluation of biological activity of triterpenoid saponins from Maesa lanceolata”,Journal of Natural Products, May, 1998, 61:5, 585-590.
Sindambiwe, J. et al., “Triterpenoid saponins from Maesa Lanceolata”,Phytochemistry, 1996, 41:1, 269-277.
De Kimpe Norbert G. M.
Germonprez Nils Albert Gilbert
Maes Louis Jules Roger Marie
Ngoc Ninh Tran
Van Puyvelde Luc Emiel Mathilde
Janssen Pharmaceutica N.V.
Qazi Sabiha
Woodcock & Washburn LLP
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