Antiprotozoal diamidines

Details Antiprotozoal diamidines Antiprotozoal diamidines

1983-04-14

1985-10-08

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

548342, 548251, 548561, 514381, 514386, 514398, 514427, 564243, A61K 31155, C07C12300

Patent

active

045461139

ABSTRACT:
Diamidines of the formula ##STR1## wherein X is a propylene, isobutylene, guanidine, pyrrole, tetrazole, imidazole or substituted imidazole group; and 2-[4-(2-imidazolinyl)phenyl]-6-(2-imidazolinyl)indole, are useful in the treatment of certain protozoal infections in mammals, particularly in cattle.

REFERENCES:
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patent: 3652591 (1972-03-01), Dann
patent: 3689506 (1972-09-01), Dann
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Das et al., [A] J. Med. Chem., vol. 20, pp. 531-536, (1977); [B] vol. 20, pp. 1219-1221, (1977); [C] vol. 23, pp. 578-581, (1980).
Dann et al., [A] Ann., vol. 749, pp. 68-89, (1971); [B] pp. 160-194, (1975).
Berg, J. Chem. Soc., pp. 5097-5101, (1961).
Anne et al., Antimicrobial Agents and Chemotherapy, vol. 18, pp. 231-239, (1980).
Clercq et al., J. Med. Chem., vol. 23, pp. 787-795, (1980).
Steck et al., Experimental Parasitology, vol. 52, pp. 404-413, (1981).

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