Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-12-11
1991-10-01
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514682, A61K 3144
Patent
active
050534181
ABSTRACT:
Novel combinations of an antiprotozoal naphthoquinone and a 4-pyridinol or an alkanoic ester thereof wherein the antiprotozoal activity of the combination is potentiated with respect to the corresponding activity of the components of the combination. The combinations are especially useful for the treatment or porphylaxis of malaria.
REFERENCES:
patent: 2553648 (1951-05-01), Fieser et al.
patent: 3206358 (1965-09-01), Stevenson
patent: 3347742 (1967-10-01), Rogers
patent: 3367830 (1968-02-01), Sarett
Fieser, et al., Journal of Medicinal Chemistry, vol. 10, No. 1, Jun. 26, 1967, Naphthoquinone Antimalarials, XXIX, 2-Hydroxy-3-(w-cyclohexylalkyl)-1,4-naphthoquinones, pp. 513-517.
Fieser et al., vol. 70, pp. 3158-3164, Naphthoquinone Antimalarials II, Correlation of Structure and Activity Against P. Lophurae in Ducks.sup.1.
Challey et al., "Synergism Between 4-Hydroxyquinoline and Pyridone Cocidiostats", The Journal of Parasitology 59(3):502-504 (1973).
Fry et al., "Effects of Decoquinate and Clopidol on Electron Transport in Mitochondria of Eimeria Tenella", Biochemical Pharmacology, 33(2):229-240 (1984).
Wang, "Studies of the Mitochondria from Eimeria Tennella and Inhibition of the Electron Transport by Quinolone Coceidiostats", Biochimica et Biophysica Acta, 396, pp. 210-219 (1975).
Wang, "Biochemistry and Physiology of Coceidia", pp. 197-198 (1975).
Wang, "Biochemical and Nutritional Aspects of Coccidia", Avian Coccidiosis, British Poultry Science Ltd., pp. 135-184 (1978).
Hudson Alan T.
Latter Victoria S.
Randall Anthony W.
Richards William H. G.
Brown Donald
Burroughs Wellcome Co.
Travers Russell
Waddell Frederick E.
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