Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1996-02-06
1998-11-03
Prior, Kimberly J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
552653, A61K 3159, C07C40100
Patent
active
058308857
ABSTRACT:
Vitamin D.sub.3 analogues of formula ##STR1## wherein R represents a 1-hydroxyalkyl group or 1-fluoroalkyl group in a trans- configuration with a 3-hydroxyl group on the A ring and R.sup.2 represents the substituents completing a vitamin D.sub.3 analogue. These novel compounds are potent anti-proliferative substances with activities comparable to that of calcitriol but with vitamin D.sub.3 receptor binding ratings of less than 10.sup.-3 compared to that of calcitriol.
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Prior Kimberly J.
The Johns Hopkins University
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