Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-08-08
2006-08-08
Helms, Larry (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007230
Reexamination Certificate
active
07087392
ABSTRACT:
The invention provides methods and compositions relating to activated Sgk and the association of activated Sgk activity with proliferating cells, including methods for inhibiting the growth of an undesirably proliferating cell by contacting the cell with a specific inhibitor of activated Sgk whereby the amount of activated Sgk activity in the cell is reduced. Specific inhibitors are disclosed, including dominant negative mutants of activated Sgk, an Sgk mutant or fragment thereof comprising an unphosphorylatable residue corresponding to Thr256 of native Sgk, and an active Sgk-specific antibody or antibody fragment, especially intrabody, etc. A wide variety of methods may be used to contact the target cell with the inhibitor, especially introducing into the cell a polynucleotide encoding the inhibitor under conditions whereby the inhibitor is expressed in the cell.
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Webster et al. Mol. Cell. Biol., 1993, 13(4): 2031-2040.
Delmolino et al., 1997, Journal of Cellular Physiology 173:371-79.
Park et al., 1999, The EMBO Journal 18(11):3024-33.
Bell Lisa M.
Buse Patricia
Firestone Gary L.
Leong Meredith L. L.
Maiyar Anita C.
Helms Larry
Osman Richard Aaron
Sang Hong
The Regents of the University of California
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