Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1990-11-14
1997-08-19
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
536 235, 536 2431, 435 691, 435 712, 4352523, 4351723, 4353201, 935 11, 935 29, 935 56, 935 72, 935 73, C12N 1512, C12N 1563, C12N 121, C07K 1447
Patent
active
056587929
ABSTRACT:
The subject invention relates to a novel mammalian antiproliferative protein, prohibitin, and uses thereof. For example, prohibitin may be utilized in the treatment of diseases involving excess cellular replication, such as cancer, or in the treatment of conditions involving an insufficient amount of cellular replication, such as impaired tissue regeneration.
REFERENCES:
P.D. Eveleth et al. "Sequence and Expression of the Cc Gene . . ." Nuc. Acids. Res. 14(15)6169-6183 (1986).
M.J. Nuell et al. "Molecular and Genetic Analysis of Prohibitin . . . " J. Cell. Biochem. 14C:307 Abst. #1418 (Feb. 1990).
McClung, J.K. et al. "Isolation of a cDNA that Hybrid Selects Antiproliferative mRNA from Rat Liver." Biochem., Biophys. Res. Commun. 164(3)1316-1322 (Nov. 1989).
Danner David B.
McClung J. Keith
Nuell Mark J.
Stewart David A.
Prouty Rebecca
The United States of America as represented by the Department of
Wax Robert A.
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