Antiproliferative factor from patients with interstitial cystiti

Details Antiproliferative factor from patients with interstitial cystiti Antiproliferative factor from patients with interstitial cystiti

1997-10-03

1999-10-05

Hutzell, Paula K.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 4, 435 723, C07K 100, C12G 100, G01N 33574

Patent

active

059626453

ABSTRACT:
A novel antiproliferative factor (APF) present in urine of patients with interstitial cystitis (IC) is described. This urine antiproliferative factor can serve as a marker for disease activity and its antagonists as therapeutic medicaments for IC. In addition, APF and its agonists can be used for treating diseases associated with cell proliferation.

REFERENCES:
Tao et al., J Immunology, 143: 2595-2601, 1989.
Lazar et al. Molecular and Cellular Biology 8: 1247-1252, 1988.
Burgess et al., J Cell Biol. 111: 2129-2138, 1990.

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