Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-09-22
1996-11-12
Gupta, Yogendra N.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142328, 514255, 514411, 544122, 544153, 544249, 544372, 548427, 548440, 548441, 548450, A61K 31505, A61K 3140, C07D23970, C07D20964
Patent
active
055740391
ABSTRACT:
The invention relates to TS-inhibiting compounds of the formula ##STR1## where W is an alkylene group; D is a structure having two rings that are unsubstituted or substituted, where (i) one ring is a phenyl ring and (ii) the other ring is a phenyl ring or a 6-membered heterocyclic ring; R is a hydrogen atom or an alkyl group; and X and Y together form ##STR2## and to salts of these compounds. The moiety W can be CH.sub.2, and D can be a phenyl ring bridged through a sulfonyl group to another ring.
REFERENCES:
patent: 3291808 (1966-12-01), Elslager et al.
patent: 3330834 (1967-07-01), Senshu et al.
patent: 3347865 (1967-10-01), Brack et al.
patent: 3853913 (1974-12-01), Brack et al.
patent: 3959310 (1976-05-01), Brack et al.
patent: 3963747 (1976-06-01), Schefczik et al.
patent: 4147865 (1979-04-01), Harnisch et al.
patent: 4200752 (1980-04-01), Bertelson
patent: 4598151 (1986-07-01), Kuhlthau et al.
patent: 4857530 (1989-08-01), Berman et al.
patent: 5147568 (1992-09-01), Luzzi et al.
Takahashi, Chemical Abstracts, Synthesis of 3-aminonaphthostyril Derivatives and Their Antibacterial Activities, 90:186709z (1979).
Lugovskii et al., Chemical Abstracts, Synthesis of 4-(alkylamino)naphthalimides and Their Luminescence and Orientations . . . , 109:210872f (1988).
Jones et al., "Quinazoline Antifolates Inhibiting Thymidylate Synthase: Variation of N.sup.10 Substituent," J. Med. Chem. 28, 1468-1476 (1985).
Jones et al., "Quinazoline Antifolates Inhibiting Thymidylate Synthase: Variation of the Amino Acid," J. Med. Chem. 29, 1114-1118 (1986).
Jones et al., "Quinazoline Antifolates Inhibiting Thymidylate Synthase: Benzoyl Ring Modifications," J. Med. Chem. 29, 468-472 (1986).
Brixner et al., "Folate Analogues as Inhibitors of Thymidylate Synthase," J. Med. Chem. 30, 675-678 (1987).
Deal Judith P.
Jones Terence R.
Marzoni Gifford P.
Palmer Cynthia L.
Varney Michael D.
Agouron Pharmaceuticals , Inc.
Gupta Yogendra N.
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