Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-08-01
2000-10-03
Aulakh, Charanjit S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546326, 546321, 546314, 514356, A61K 3144, C07D21304
Patent
active
061273937
ABSTRACT:
An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents chelate metals in metal containing protein complexes required for growth, replication or inflammatory response. The preparations can be administered systemically or for topical use. The preparations have antineoplastic, antiviral, antiinflammatory and antiproliferative effects and are used in the treatment of warts, psoriasis, acne, skin cancers, sunburn and other proliferative diseases and in the prevention of sexually transmitted diseases such as genital warts, herpes and AIDS. The agents also can be used to induce autologous immunological response.
REFERENCES:
patent: 3903285 (1975-09-01), Umezawa et al.
patent: 4044140 (1977-08-01), Sherlock
patent: 4120762 (1978-10-01), Sviokla
patent: 4293547 (1981-10-01), Lewis et al.
patent: 4443459 (1984-04-01), Yano et al.
patent: 4814351 (1989-03-01), Mathews et al.
patent: 5057320 (1991-10-01), Evans et al.
patent: 5157046 (1998-10-01), Van Wauwe et al.
patent: 5164414 (1992-11-01), Vincent et al.
patent: 5173486 (1992-12-01), Monkovic et al.
patent: 5219847 (1993-06-01), Taguchi et al.
patent: 5284840 (1994-02-01), Rupprecht et al.
patent: 5391537 (1995-02-01), Takabe et al.
patent: 5403816 (1995-04-01), Takabe et al.
patent: 5484951 (1996-01-01), Kun et al.
patent: 5516941 (1996-05-01), Kun et al.
patent: 5536743 (1996-07-01), Borgman
patent: 5767135 (1998-06-01), Fernandez-Pol
patent: 6001555 (1999-12-01), Henderson et al.
Elisabetta Blasi, et al., Protective Effect of Picolinic Acid on Mice Intracerebrally Infected with Lethal Doses of Candida albicans; Antimicrobial Agents and Chemotherapy, Nov. 1993 pp. 2422-2426 vol. 37, No. 11.
Giovanni Melillo et al., Regulation of Nitric-oxide Synthase mRNA Expression by Interferon-.gamma. and Pocolinic Acid, The Journal of Biological Chemistry vol. 269, No. 11 Issue of Mar. 18, pp. 8128-8133, 1994.
Elisabetta Blasi et al., Inhibition of Retroviral mRNA Expression In The Murine Macrophage Cell Line GG2EE by Biologic Response Modifiers.sup.1 ; The Journal of Immumology vol. 141 pp. 2153-2157 No. 6 Sep. 15, 1988.
Takashi Mikagami et al., Effect of intracellular iron depletion by picolinic acid on expression of the lactoferrin receptor in the human colon carcinoma cell subclone HT29-18C.sub.1: ; Biochem J. (1995) 308 391-397 (Printed in Great Britain).
George W. Cox et al., IL-4 Inhibits the Costimulatory Activity of IL-2 Or Pocolinic Acid But Not Of Lipopolysaccharide on IFN .gamma. Treated Macrophages; The Journal of Immunology vol. 147 3809-3814 No. 11, Dec. 1, 1991.
Elisabetta Blasi et al., Pattern of cytokine gene expression in brains of mice protected by picolinic acid against lethal intracerebral infection with Candida albicans; Journal of Neuoimmumology 52 (1994) 205-213.
Giovanni Melillo, Picolinic Acid, a Catabolite of L-Tryptophan, Is a Costimulus for the Induction of Reactive Nitrogen Intermediate Production in Murine Macrphages; The Journal of Immumology vol. 150 4031-4040 No. 9 May 1, 1993.
Ann M. Bode et al., Inhibition of glucose-6 phosphate phosphohydrolase by 3-mercaptopicolinate and two anologs is metabolically directive; Biochem Cell Biol, vol. 71, 1993 pp. 113-121.
L. Vrooman et al., Picolinic Acid modulates kainic acid-evoked glutamate release from the striatum in vitro; Brain Research 627 (1993) 193-198.
L. Varesio et al., Ribosomal RNA Metabolism in Macrophages, Current Topics In Microbiology and Immunology vol. 181 1992.
Alan D. Frankel et al. Cellular Uptake of the Tat Protein from Human Immunodeficiency Virus, Cell, vol. 55, 1189-1193, Dec. 23, 1988.
J. Alberto Fernandez-Pol et al., Anticancer Research, Expression of Metallopanstimulin in Condylomata Acuminata of the Female Anogenital Region Induced by Papilloma Virus, pp. 773-785.
Dennis J. Bobilya et al., Ligands Influence Zn Transport into Cultured Endothelial Cells, pp. 159-166.
Stephan P. Clancy et al., Effects of Chromium Picolinate Supplementation on Body Composition, Strength, and Urinary Chromium Loss in Football Players; Original Research, International Journal of Sport Nutrition, 1994 142-153 1994 Human Kinetics Publishers, Inc.
Nancy A. Lee et al., Beneficial Effect of Chromium Supplementation on Serum Triglyceride Levels in NIDDM, Diabetes Care vol. 17 No. 12 Dec. 1994.
T.G. Page et al. Effect of Chromium Picolinate on Growth and Serum and Carcass Traits of Growing-Finishing Pigs .sup.1,2,3 J. Anim. Sci. 1993 71:656-662.
M.D. Lindemann.sup.2 Dietary Chromium Picolinate Additions Improve Gain:Feed and Carcass Characteristics in Growing-Finishing Pigs and Increase Litter Size in Reproducing Sows.sup.1 ; J. Anim. Sci. 1995 73: 457-465.
G. W. Evans et al., Chromium Picolinate Increases Membrane Fluidity and Rate of Insulin Internalization, Journal of Inorganic Biochemistry 46, pp. 243-250 (1992).
G. W. Evans et al. Composition and Biological Activity of Chromium-Pyridine Carboxylate Complexes, Journal of Inorganic Biochemistry 49, pp. 177-187 (1993).
J. A. Fernandez-Pol et al., Control of growth by picolinic acid: Differential response of normal and transformed cells; Cell Biology; vol. 74, No. 7 pp. 2889-2893, Jul. 1977.
J. A. Fernandez-Pol, Isolation and Characterization of a Siderophore-Like Growth Factor from Mutants of SV40-Transformed Cells Adapted to Picolinic Acid, Cell vol. 14, 489-499, Jul. 1978.
T.L. Varadinova et al., Mode of Action of Zn-Complexes on Herpes Simplex Virus Type 1 Infection In Vitro, Journal of Chemotherapy, vol. 5, 3-9 1993.
J. Albert Fernandez-Pol, Growth Factors, Oncogenes, Antioncogenes and Aging, Geriatric Oncology, Chapter 7, pp. 60-75, 1992.
J. A. Fernandez-Pol; Morphological Changes Induced by Picolinic Acid in Cultured Mammalian Cells; Experimental and Molecular Pathology 29; 348-357 (1978).
J. A. Fernandez-Pol et al., NRK Cells Synchronized In G.sub.1 By Picolinic Acid Are Super-Sensitive To Prostaglandin E.sub.1 Stimulation, vol. 74, No. 2; Febs Letters, Mar. 1977.
J. A. Fernandez-Pol, Peptide and Protein Complexes of Transition Metals as Modulators of Cellular Replication; International Journal of Nuclear Medicine and Biology vol. 8 pp. 231-235 (1981).
J. A. Fernandez-Pol et al., Iron Transport In NRK Cells Synchronized In G.sub.1 By Picolinic Acid, Cell Biology International al Reports, vol. 2, No. 5, pp. 433-439 (1978).
J. A. Fernandez-Pol, Iron: Possible Cause of the G.sub.1 Arrest Induced In NRK Cells By Picolinic Acid; Biochemical And Biophysical Research Communications, vol. 78, No. 1, pp. 136-143, 1977.
J. A. Fernandez-Pol, Transition Metals Ions Induce Cell Growth In NRK Cells Synchronized In G.sub.1 By Picolinic Acid, vol. 76, No. 2, Biochemical And Biophysical Research Communications pp. 413-419 (1977).
J. A. Fernandez-Pol et al., Selective Toxicity Induced by Picolinic Acid in Simian Virus 40-transformed Cells in Tissue Culture, Cancer Research 37, 4276-4279, (Dec. 1977).
Michael L. Gargas et al. Urinary Excretion of Chromium by Humans Following Ingestion of Chromium Picolinate; Drug Metabolism and Disposition, vol. 22, No. 4 pp. 522-529 (1994).
Letter to the Editor; Chromium Picolinate is an Efficacious and Safe Supplement; International Journal of Sport Nutrition, 1993 p. 117-122, 1993 Human Kinetics Publishers Inc.
An Inexpensive, Convenient Adjunct for the Treatment of Diabetes, The Western Journal of Medicine Nov. 1991 p. 549.
R. J. Boegman et al., Neurotoxicity of Tryptophan Metabolities; Annals New York Academy of Sciences vol. 585 1990 pp. 261-273.
Raymond I. Press, MD, et al., The Effect of Chromium Picolinate on Serum Cholesterol and Apoliprotein Fractions in Human Subject, West J Med 1990 Jan; 152:41-45.
Anna Shapiro et al. In Vivo and In Vitro activity by Diverse Chelators against Trypanosoma brucei brucei.sup.1, The Journal of Protozoology, vol. 29, No. 1, Feb. 1982.
Komatsu, et al. Viral RNA Binding Properties of Human Immunodeficieny Virus Type-2 (HIV-2) Nucleocapsid Protein-Derived Synthetic Peptides, Biochemistry and Molecular Biology International,
Aulakh Charanjit S.
Novactyl, Inc.
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