Antiproliferative agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S475000

Reexamination Certificate

active

07049338

ABSTRACT:
This invention relates to certain dioxodihydropyridine derivatives and certain methacrylic acid and furan derivative precursors thereof, processes for their preparation, pharmaceutical compositions containing such compounds and their use as anti-proliferative agents, especially tumor growth inhibitors and anti-cancer agents, antibiotics and/or antiviral agents.

REFERENCES:
patent: 0403240 (1990-12-01), None
patent: 48 090982 (1973-11-01), None
patent: 0125034 (1989-05-01), None
patent: 06100513 (1994-12-01), None
Romdhane et al.; “A Model study for Diels—Alder reaction of biscyclopentadienyl monomer with bismaleimides. Benzylcyclopentadiene: synthesis, Characterization and Diels—Alder reaction with N-(4-benzoyl)- phenylmaleimide.”Polymer41, 1633-1639 (2000).
Andreozzi, et al.; “Reactivity Towards Ozone of 2-Hydroxypyridine in Aqueous Solution.”Ozone Science&Engineering14, 177-184 (1992).
Smolanka et al.; “Some data on antimicrobial activity of the 4(5)-oxazolone and 4(5)- thiazolone derivatives”Fiziol. AKT. Veshchestva31-5 (1966).
Kaleagasiglu et al.; “Antiproliferative Activity of Retinoic Acid and Some Novel Retinoid Derivatives in Breast and Colorectal Cancer Cell Lines of Human Origin1.”Arzneim-Forsch/Drugs Res43 (I),Nr, 4 (1993).
Hixson et al.; “Antiproliferative Effect of Nonsteroidal Antiinflammatory Drugs against Human Colon Cancer Cells1.”Cancer Epidemiology, Blomarkers&Prenvention3, 433-438 (1994).
Rao et al.; “Electrochemical Studies of Some Amide Derivatives.”Transactions of the SAEST32, 2-3 (1997).

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