Antiproliferative agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C546S188000, C546S261000, C514S348000

Reexamination Certificate

active

06881846

ABSTRACT:
This invention relates to certain dioxodihydropyridine derivatives and certain methacrylic acid and furan derivative precursors thereof, processes for their preparation, pharmaceutical compositions containing such compounds and their use as anti-proliferative agents, especially tumour growth inhibitors and anti-cancer agents, antibiotics and/or antiviral agents.

REFERENCES:
patent: 0403240 (1990-12-01), None
patent: 48 090982 (1973-11-01), None
patent: 0125034 (1989-05-01), None
patent: 06100513 (1994-12-01), None
Romdhane et al.; “A Model study for Diels—Alder reaction of biscyclopentadienyl monomer with bismaleimides. Benzylcyclopentadiene: synthesis, Characterization and Diels—Alder reaction with N-(4-benzoyl)- phenylmaleimide.”Polymer 41, 1633-1639(2000).
Andreozzi, et al.; “Reactivity Towards Ozone of 2-Hydroxypyridine in Aqueous Solution.”Ozone Science&Engineering 14, 177-184(1992).
Smolanka et al.; “Some data on antimicrobial activity of the 4(5)-oxazolone and 4(5)-thiazolone derivatives”Fiziol. AKT. Veshchestva 31-5(1966).
Kaleagasiglu et al.; “Antiproliferative Activity of Retinoic Acid and Some Novel Retinoid Derivatives in Breast and Colorectal Cancer Cell Lines of Human Origin1.”Arzneim-Forsch/Drug Res 43(1),Nr. 4(1993).
Hixson et al.; “Antiproliferative Effect of Nonsteroidal Antiinflammatory Drugs against Human Colon Cancer Cells1.”Cancer Epidemiology, Blomarkers&Prenvention 3, 433-438(1994).
Rao et al.; “Electrochemical Studies of Some Amide Derivatives.”Transactions of the SAEST 32, 2-3(1997).

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