Antiproliferative activity of g-rich oligonucleotides and...

Details Antiproliferative activity of g-rich oligonucleotides and... Antiproliferative activity of g-rich oligonucleotides and...

2008-01-01

2008-01-01

Sullivan, Daniel M. (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C514S04400A

Reexamination Certificate

active

09958251

ABSTRACT:
The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin-like in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection.

REFERENCES:
patent: 5176996 (1993-01-01), Hogan et al.
patent: 5262409 (1993-11-01), Margolis et al.
patent: 5310892 (1994-05-01), Aris et al.
patent: 5342774 (1994-08-01), Boon et al.
patent: 5359047 (1994-10-01), Donahue et al.
patent: 5416202 (1995-05-01), Bernhard et al.
patent: 5432070 (1995-07-01), Schumacher et al.
patent: 5443962 (1995-08-01), Draetta et al.
patent: 5444149 (1995-08-01), Keene et al.
patent: 5449758 (1995-09-01), Hartley
patent: 5470971 (1995-11-01), Kondo et al.
patent: 5489508 (1996-02-01), West et al.
patent: 5494818 (1996-02-01), Baker et al.
patent: 5495070 (1996-02-01), John
patent: 5523389 (1996-06-01), Ecker et al.
patent: 5561222 (1996-10-01), Keene et al.
patent: 5582981 (1996-12-01), Toole et al.
patent: 5583016 (1996-12-01), Villeponteau et al.
patent: 5594120 (1997-01-01), Brenner et al.
patent: 5612201 (1997-03-01), De Plaen et al.
patent: 5614503 (1997-03-01), Chaudhary et al.
patent: 5624799 (1997-04-01), Kohwi-Shigematsu et al.
patent: 5624818 (1997-04-01), Eisemann et al.
patent: 5625031 (1997-04-01), Webster et al.
patent: 5631146 (1997-05-01), Szostak et al.
patent: 5643778 (1997-07-01), Nishikura
patent: 5643890 (1997-07-01), Iversen et al.
patent: 5645986 (1997-07-01), West et al.
patent: 5656430 (1997-08-01), Chirikjian et al.
patent: 5670621 (1997-09-01), Donahue et al.
patent: 5677428 (1997-10-01), Nishikura
patent: 5686306 (1997-11-01), West et al.
patent: 5688511 (1997-11-01), Gaynor et al.
patent: 5691145 (1997-11-01), Pitner et al.
patent: 5695932 (1997-12-01), West et al.
patent: 5705334 (1998-01-01), Lippard et al.
patent: 5707795 (1998-01-01), West et al.
patent: 5714575 (1998-02-01), Inouye et al.
patent: 5734040 (1998-03-01), Weeks et al.
patent: 5741677 (1998-04-01), Kozlowski et al.
patent: 5756710 (1998-05-01), Stein et al.
patent: 5763174 (1998-06-01), Nishikura
patent: 5763178 (1998-06-01), Chirikjian et al.
patent: 5776696 (1998-07-01), Salowe
patent: 5780447 (1998-07-01), Nienhuis
patent: 5780610 (1998-07-01), Collins et al.
patent: 5783398 (1998-07-01), Marcy et al.
patent: 5792613 (1998-08-01), Schmidt et al.
patent: 5804380 (1998-09-01), Harley et al.
patent: 5834247 (1998-11-01), Comb et al.
patent: 5837453 (1998-11-01), Harley et al.
patent: 5837857 (1998-11-01), Villeponteau et al.
patent: 5843732 (1998-12-01), Davis et al.
patent: 5849564 (1998-12-01), Chang et al.
patent: 5854223 (1998-12-01), Stein et al.
patent: 5861498 (1999-01-01), Alnemri et al.
patent: 5863726 (1999-01-01), Harley et al.
patent: 5866680 (1999-02-01), Keene et al.
patent: 5888739 (1999-03-01), Pitner et al.
patent: 5891639 (1999-04-01), Harley et al.
patent: 5925729 (1999-07-01), Boon et al.
patent: 5932475 (1999-08-01), Bandman et al.
patent: 5932556 (1999-08-01), Tam
patent: 5948680 (1999-09-01), Baker et al.
patent: 5952490 (1999-09-01), Hanecak et al.
patent: 5968506 (1999-10-01), Weinrich et al.
patent: 5972692 (1999-10-01), Hashimoto et al.
patent: 5985320 (1999-11-01), Edwards et al.
patent: 5989823 (1999-11-01), Jayasena et al.
patent: 5989860 (1999-11-01), Bandman et al.
patent: 5994072 (1999-11-01), Lam et al.
patent: 6013639 (2000-01-01), Peyman et al.
patent: 6017536 (2000-01-01), Barney et al.
patent: 6017709 (2000-01-01), Hardin et al.
patent: 6020139 (2000-02-01), Schwartz et al.
patent: 6025194 (2000-02-01), Funk
patent: 6025474 (2000-02-01), Van den Eynde et al.
patent: 6027881 (2000-02-01), Paviakis et al.
patent: 6028058 (2000-02-01), Florkiewicz
patent: 6030955 (2000-02-01), Stein et al.
patent: 6036955 (2000-03-01), Thorpe et al.
patent: 6037329 (2000-03-01), Baird et al.
patent: 6054265 (2000-04-01), Barney et al.
patent: 6054442 (2000-04-01), Chen et al.
patent: 6057423 (2000-05-01), Brenner et al.
patent: 6060065 (2000-05-01), Barney et al.
patent: 6063906 (2000-05-01), Brenner et al.
patent: 6068973 (2000-05-01), Barney et al.
patent: 6071732 (2000-06-01), Moore
patent: 6080727 (2000-06-01), Zupi
patent: 6093399 (2000-07-01), Thorpe et al.
patent: 6093794 (2000-07-01), Barney et al.
patent: 6107029 (2000-08-01), Giordano
patent: 6121434 (2000-09-01), Peyman et al.
patent: 6126965 (2000-10-01), Kasid et al.
patent: 6127173 (2000-10-01), Eckstein et al.
patent: 6127175 (2000-10-01), Vigne et al.
patent: 6153408 (2000-11-01), Abastado et al.
patent: 6165786 (2000-12-01), Bennett et al.
patent: 6165789 (2000-12-01), Monia et al.
patent: 6166178 (2000-12-01), Cech et al.
patent: 6171843 (2001-01-01), Bandman et al.
patent: 6177254 (2001-01-01), Rattner et al.
patent: 6180348 (2001-01-01), Li
patent: 6183751 (2001-02-01), Chang et al.
patent: 6194206 (2001-02-01), West et al.
patent: 6200746 (2001-03-01), Fisher et al.
patent: 6214805 (2001-04-01), Torrence et al.
patent: 6228983 (2001-05-01), Barney et al.
patent: 6235313 (2001-05-01), Mathiowitz et al.
patent: 6235525 (2001-05-01), van den Eynde et al.
patent: 6251585 (2001-06-01), Draetta et al.
patent: 6255055 (2001-07-01), Ross
patent: 6261556 (2001-07-01), Weinrich et al.
patent: 6265548 (2001-07-01), Paviakis et al.
patent: 6274313 (2001-08-01), Weeks et al.
patent: 6274725 (2001-08-01), Sanghvi et al.
patent: 6288042 (2001-09-01), Rando et al.
patent: 6291187 (2001-09-01), Kingsmore et al.
patent: 6300321 (2001-10-01), Scherman et al.
patent: 6313266 (2001-11-01), Bandman et al.
patent: 6316200 (2001-11-01), Nadeau et al.
patent: 6320039 (2001-11-01), Villeponteau et al.
patent: 6323185 (2001-11-01), Rando et al.
patent: 6331396 (2001-12-01), Silverman et al.
patent: 6331617 (2001-12-01), Weeks et al.
patent: 6332897 (2001-12-01), Weiner et al.
patent: 6333191 (2001-12-01), Inouye et al.
patent: 6333314 (2001-12-01), Kasid et al.
patent: 6335170 (2002-01-01), Orntoft
patent: 6348586 (2002-02-01), Chang et al.
patent: 6355785 (2002-03-01), Rando et al.
patent: 6365187 (2002-04-01), Mathiowitz et al.
patent: 6368789 (2002-04-01), West et al.
patent: 6376226 (2002-04-01), Alnermri
patent: 6379888 (2002-04-01), Nadeau et al.
patent: 6383752 (2002-05-01), Agrawal et al.
patent: 6399302 (2002-06-01), Lannigan et al.
patent: 6399392 (2002-06-01), Haugland et al.
patent: 6416959 (2002-07-01), Giuliano et al.
patent: 6420122 (2002-07-01), Housman et al.
patent: 6423493 (2002-07-01), Gorenstein et al.
patent: 6426231 (2002-07-01), Bayley et al.
patent: 6444643 (2002-09-01), Steiner et al.
patent: 6444870 (2002-09-01), Zhang et al.
patent: 6455042 (2002-09-01), Brenner et al.
patent: 6455250 (2002-09-01), Aguilera et al.
patent: 6465176 (2002-10-01), Giordano et al.
patent: 6475789 (2002-11-01), Cech et al.
patent: 6475791 (2002-11-01), Lippard et al.
patent: 6479055 (2002-11-01), Bolognesi et al.
patent: 6479301 (2002-11-01), Balch et al.
patent: 2001/0041681 (2001-11-01), Phillips et al.
patent: WO 99/07383 (1999-02-01), None
patent: WO 99/42113 (1999-08-01), None
patent: WO 01/44465 (2001-06-01), None
US 6,020,459, 02/2000, Barney et al. (withdrawn)
Burgess et al. The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism. Proc Natl Acad Sci U S A. Apr. 25, 1995;92(9):4051-5.
Dermer G. Another Anniversary for the war on cancer, 1994, Bio/Technol. 12:320.
Zendegui et al. In vivo stability and kinetics of absorption and disposition of 3′ phosphopropyl amine oligonucleotides. Nucleic Acids Res. Jan. 25, 1992;20(2):307-14.
Dapic et al. Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications. Biochemistry. Mar. 19, 2002;41(11):3676-85.
Ohnuma et al. Inhibitory effects of telomere-mimic phosphorothioate

Affiliated with

Also associated with

Rating

Antiproliferative activity of g-rich oligonucleotides and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antiproliferative activity of g-rich oligonucleotides and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antiproliferative activity of g-rich oligonucleotides and... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3948914