Antiproliferative activity of g-rich oligonucleotides and...

Details Antiproliferative activity of g-rich oligonucleotides and... Antiproliferative activity of g-rich oligonucleotides and...

2008-01-01

2008-01-01

Sullivan, Daniel M. (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C514S04400A

Reexamination Certificate

active

07314926

ABSTRACT:
The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin-like in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection.

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