Antiproliferative activity of G-rich oligonucleotides and...

Details Antiproliferative activity of G-rich oligonucleotides and... Antiproliferative activity of G-rich oligonucleotides and...

2011-06-14

2011-06-14

McGarry, Sean (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S024300, C536S024330

Reexamination Certificate

active

07960540

ABSTRACT:
Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.

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