Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-10-30
2007-10-30
Anderson, Rebecca (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S127000
Reexamination Certificate
active
11218969
ABSTRACT:
This invention is directed to methods of using compounds having the structure:and including stereoisomers, solvates, and pharmaceutically acceptable salts thereof, wherein each of R1, R2, R3and R4is independently selected from hydrogen, R5, R6, and R7; R5is selected from alkyl, heteroalkyl, aryl and heteroaryl; R6is selected from (R5)n-alkylene, (R5)n-heteroalkylene, (R5)n-arylene and (R5)n-heteroarylene; R7is selected from (R6)n-alkylene, (R6)n-heteroalkylene, (R6)n-arylene, and (R6)n-heteroarylene; and n is selected from 0, 1, 2, 3, 4 and 5, where R1and R2may together form a heterocyclic structure including the nitrogen to which they are both attached, and R3and R4may together form a heterocyclic structure including the nitrogen to which they are both attached; and each of L1and L2is independently selected from -A1-A2-A3- where each of A1, A2, and A3 is independently selected from a direct bond, alkylene, heteroalkylene, arylene and heteroarylene. These compounds are useful in treating hyperproliferative disorders and inducing apoptosis.
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Chopiuk Gregory B
Daynard Timothy S
Wang Shisen
Zhang Zaihui
Anderson Rebecca
Chung Susannah
QLT Inc.
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