Antiproliferative 1,2,3-thiadiazole compounds

Details Antiproliferative 1,2,3-thiadiazole compounds Antiproliferative 1,2,3-thiadiazole compounds

2006-04-04

2006-04-04

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S361000, C544S134000, C548S127000

Reexamination Certificate

active

07022702

ABSTRACT:
Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical formulations are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are 1,2,3-thiadiazoles having the structure:and including stereoisomers, solvates, and pharmaceutically acceptable salts thereof, wherein each of R1, R22 , R3and R4is independently selected from hydrogen, R5R6, and R7, R5is selected from alkyl, heteroalkyl, aryl and heteroaryl; R6is selected from (R5)n-alkylene, (R5)n-heteroalkylene, (R5)n-arylene and (R5)n-heteroarylene; R7is selected from (R6)n-alkylene, (R6)n-heteroalkylene, (R6)n-arylene, and (R6)n-heteroarylene; and n is selected from 0, 1, 2, 3, 4 and 5, where R1and R2may together form a heterocyclic structure including the nitrogen to which they are both attached, and R3and R4may together form a heterocyclic structure including the nitrogen to which they are both attached; and each of L1and L2is independently selected from -A1-A2-A3- where each of Al, A2, and A3 is independently selected from a direct bond, alkylene, heteroalkylene, arylene and heteroarylene.

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