Antiproliferation factor

Details Antiproliferation factor Antiproliferation factor

1994-05-10

1996-06-04

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530351, 5303871, 5303887, 53038873, 53038875, 5303888, 5303896, 5303897, 530854, 530395, 514 12, 424 851, C07K 1452, C07K 1624, A61K 3819

Patent

active

055232906

ABSTRACT:
Mammalian pituitary discovered anti-proliferation factor that inhibits in vitro cellular proliferation of lymphoid, neuroendocrine and neural cells but not of fibroblast or endothelial cells. The present invention is directed to this antiproliferation factor which has been named suppressin and is a protein of Mr 63,000, sensitive to reduction and has a pI of 8.1. Suppressin is provided as a cell free preparation or in homogeneous form. The invention provides methods to purify suppressin, antibodies against suppressin and their use recombinant DNA molecules encoding suppressin, and pharmaceutical compositions for inducing regression or inhibiting growth of tumor or cancel cells and autoimmune diseases.

REFERENCES:
patent: 4289690 (1981-09-01), Pestka et al.
patent: 5187077 (1993-02-01), Gearing et al.
Hird et al. 1990. Genes and Cancer, (eds.) Carney et al., John Wiley and Sons, Ltd., N.Y., pp. 183-189.

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