Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-12-18
2007-12-18
Robinson, Hope (Department: 1652)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S350000
Reexamination Certificate
active
10774242
ABSTRACT:
Human α2-antiplasmin (α2AP) is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin. Two forms of α2AP circulate in human plasma: a 464-residue protein, which we have termed “pro”-form, or α2APpro, and an N-terminally-shortened 452-residue “activated”-form, or α2APact. The latter becomes crosslinked to fibrin by activated factor XIII about 5-fold more rapidly than α2APproand makes fibrin resistant to digestion by plasmin. A new human plasma proteinase has been identified herein that cleaves the Pro12-Asn13 bond of α2APproto yield α2APact. This enzyme is identified herein as Antiplasmin Cleaving Enzyme (APCE).
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Christiansen Victoria J.
Jackson Kenneth W.
Lee Kyung N.
McKee Patrick A.
Dunlap Codding & Rogers P.C.
Robinson Hope
The Board of Regents of the University of Oklahoma
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