Antiplasma animal model

Details Antiplasma animal model Antiplasma animal model

1996-06-07

1998-09-08

Chambers, Jasemine C.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

800 2, 424 92, 4241301, 435 72, 435375, 4351723, A61K 4800, C12N 1563, C07K 1600

Patent

active

058041591

ABSTRACT:
There is disclosed an anti-plasma antibody preparation for treatment of a mammal, which preparation is capable of directly or indirectly inhibiting and/or eliminating several blood factors, a method of producing such a preparation and a method of evaluating substances for treating clotting disorders by using said anti-plasma antibody preparation. There is further disclosed a method of determining the bleeding characteristics of a mammal.

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Giles et al., Blood, 60(3): 727-730 (Sep. 1982).
Novak et al., British Journal of Haematology 69: 371-378 (1988).
Ruggeri et al., Blood, 57(6): 1140-1143 (Jun. 1981).
Aihara et al., Thrombosis & Haemostasis, 55(2): 263-267 (1980).
The Merk Manual or Diagnosis and Therapy, Ed. Berkow et al., 16th edition, Merck & Co., Inc., Rahway, N.J., 1992.
Brinkhous et al. "von Willebrand Factor and Animal Models: Contributions to Gene Therpy, Thrombotic Thrombocytopenic Purpura, and Coronary Artery Thrombosis," Mayo Clin Proc, vol. 66:733-742, 1991.
Table of Proteins of Human Blood Plasma, Reagents of Behringwerke, Schultze and Heremans, Elsevier, 1966.
Tiarks et al. "Hypothesis for the Control of Clotting Factor VIII Inhibitory Antibodies by Decreasing Potency of Helper T-cell-Recognized Epitopes in Factor VIII" Scand. J. Immunol., vol. 36: 653-660, 1992.
Carmona et al., Thrombosis Reserach 63: 73-84 (1991).
Gawryl et al., Blood 60(5): 1103-1109 (1982).

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