Antipicornaviral compounds, their preparation and use

Details Antipicornaviral compounds, their preparation and use Antipicornaviral compounds, their preparation and use

2005-06-14

2005-06-14

Low, Christopher S. F. (Department: 1653)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C560S128000, C548S534000, C562S553000

Reexamination Certificate

active

06906198

ABSTRACT:
Peptido and peptidomimetic compounds of the formula:wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.

REFERENCES:
patent: 5856530 (1999-01-01), Webber et al.
Kaldor et al., “Glutamine-Drived Aldehydes For The Inhibition of Human Rhinovirus 3C Protease”, Bioorganic & Medicinal Chemistry Letters, 5 (17), 2021-2026 (1995).
Murray et al., “The Enantiospecific Synthesis Of Novel Lysine Analogues Incorporating a Pyrrolidine Containing Side Chain”, Tetrahedron Letters, 39, 6721-6724 (1998).

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