Antipicornaviral compounds compositions containing them and meth

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

560155, 560 19, 546329, 548248, 548329, 549 22, 549 39, 514351, 514378, 514423, 514436, A61K 31215, C07C29902

Patent

active

060203714

ABSTRACT:
Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.

REFERENCES:
patent: 5344957 (1994-09-01), Bovy et al.
Hanzlik et al., "Vinylogous Amino Acid Esters: A New Class of Inactivators for Thiol Proteases," J. Med. Chem., vol. 27, No. 6, Jun. 1984, pp. 711-712.
Thompson et al., "Carboxyl-Modified Amino Acids and Peptides as Protease Inhibitors," J. Med. Chem., vol. 29, No. 1, 1986, pp. 104-111.
Liu et al., "Structure-Activity Relationships for Inhibition of Papain by Peptide Michael Acceptors," J. Med. Chem., vol. 35, 1992, pp. 1067-1075.
White et al., Principles of Biochemistry, 6th Ed., McGraw Hill, 1978, pp. 893-895.
Callahan et al., "Molecular cloning and complete sequence determination of RNA genome of human rhinovirus type 14," Proc. Natl. Acad. Sci. USA, vol. 82, Feb. 1985, pp. 732-736.
Olson et al., "Structure of a human rhinovirus complexed with its receptor molecule," Proc. Natl. Acad. Sci. USA, vol. 90, Jan. 1993, pp. 507-511.
Hammerle et al., "Site-directed Mutagenesis of the Putative Catalytic Triad of Poliovirus 3C Proteinase," J. Biol. Chem., vol. 266, No. 9, 1991, pp. 5412-5416.
Orr et al., "Hydrolysis of a Series of Synthetic Peptide Substrates by the Human Rhinovirus 14 3C Proteinase, Cloned and Expressed in Escherichia coli," J. Gen. Virol, vol. 70, 1989, pp. 2931-2942.
Leong et al., "Human Rhinovirus-14 Protease 3C (3C.sup.pro) Binds Specifically to the 5'-Noncoding Region of the Viral RNA," J. Biol. Chem., vol. 268, 1993, pp. 25735-25739.
Comprehensive Medicinal Chem., vol. 2, C. Hansch, Eds., Pergamon Press, Oxford, 1990, pp. 431-433, 440-441.
Shaw, "Cysteinyl Proteinases and Their Selective Inactivation," Advance Enz, vol. 63, 1990, pp. 271-347.
Matthews et al., "Structure of Human Rhinovirus 3C Protease Reveals a Trypsin-like Polypeptide Fold, RNA-Binding Site, and Means for Cleaving Precursor Polyprotein," Cell, vol. 77, Jun. 1994, pp. 761-771.
Allaire et al., "Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases," Nature, vol. 369, May 1994, pp. 72-76.
Bazan et al., "Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: Structural and functional implications," Proc. Natl. Acad. Sci. USA, vol. 85, Nov. 1988, pp. 7872-7876.
Cordingley et al., "Cleavage of Small Peptides In Vitro by Human Rhinovirus 14 3C Protease Expressed in Escherichia coli," Journal of Virology, vol. 63, No. 12, Dec. 1989, pp. 5037-5045.
Kaldor et al,. "Glutamine-Derived Aldehydes for the Inhibition of Human Rhinovirus 3C Protease," Bioorganic & Medicinal Chemistry Letters, vol. 5, No. 17, 1995, pp. 2021-2026.
Malcolm et al., "Peptide Aldehyde Inhibitors of Hepatitis A Virus 3C Proteinase," Biochemistry, vol. 34, 1995, pp. 8172-8179.
Skiles et al., "Spiro Indolinone Beta-Lactams, Inhibitors of Poliovirus and Rhinovirus 3C-Proteinases," Tetrahedron Letters, vol. 31, No. 50, 1990, pp. 7277-7280.
Singh et al., "Structure and Stereochemistry of Thysanone; A Novel Human Rhinovirus 3C-Protease Inhibitor from Thysanophora penicilloides," Tetrahedron Letters, vol. 32, No. 39, 1991, pp. 5279-5282.
Kadam et al., "Citrinin Hydrate and Radicinin: Human Rhinovirus 3C-Protease Inhibitors Discovered in a Target-Directed Microbial Screen," The Journal of Antibiotics, vol. 47, No. 7, Jul. 1994, pp. 836-839.
Palmer et al., "Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors," J. Med. Chem., vol. 38, 1995, pp. 3913-3196.
Maryanoff et al., "Molecular basis for the inhibition of human .alpha.-thrombin by the macrocylic peptide cyclotheonamide A," Proc. Natl. Acad. Sci. USA. vol. 90, Sep. 1993, pp. 8048-8052.
Rich et al., "Synthesis of Analogues of the Carboxyl Protease Inhibitor Pepstatin. Effect of Structure on Inhibition of Pepsin and Renin," J. Med. Chem., vol. 23, 1980, pp. 27-33.
Hagihara et al., "Reassignment of Stereochemistry and Total Synthesis of the Thrombin Inhibitor Cyclotheonamide B," J. Am. Chem. Soc., vol. 114, 1992, pp. 6570-6571.
Haberson et al., "Inhibition of Aminopeptidases by Peptides Containing Ketomethylene and Hydroxyethylene Amide Bond Replacements," J. Med. Chem., vol. 32, 1989, pp. 1378-1392.
Barton et al., "Synthesis of Novel .alpha.-Amino-Acids and Derivatives Using Radical Chemistry: Synthesis of L- and D-.alpha.-Amino-Adipic Acids, L-.alpha.-Aminopimelic Acid and Appropriate Unsaturated Derivatives," Tetrahedron, vol. 43, No. 19, 1987, pp. 4297-4308.
Smith et al., "Synthesis and Renin Inhibitory Activity of Angioitensinogen Analogues Having Dehydrostatine, Leu.PSI.[CH.sub.2 S]Val, or Leu.PSI.[CH.sub.2 SO]Val at the P.sub.1 -P.sub.1 ' Cleavage Site", J. Med. Chem., vol. 31, 1988, pp. 1377-1382.
Meng et al., "Synthetic Approaches toward Glidobamine, the Core Structure of the Glidobactin Antibiotics," Tetrahedron, vol. 47, No. 32, 1991, pp. 6251-6264.
Kolter et al., "Configuratively Stable Dipeptide Aldehydes from D-Glucosamine Hydrochloride," Angew. Chem. Int. Ed. Engl., vol. 31, No. 10, 1992, pp. 1391-1392.
Reetz et al., "Stereoselective Nucleophilic Addition Reactions of Reactive Pseudopeptides," Angew. Chem. Int. Ed. Engl., vol. 31, No. 12, 1992, pp. 1626-1629.
Aoyagi et al., "Structures and Activities of Protease Inhibitors of Microbial Origin," Institute of Microbial Chemistry, Tokyo, Japan, 1975, pp. 429-454.
Rich, "Inhibitors of cysteine proteinases," Proteinase Inhibitors, Barrett and Salvesen (eds.), Elsvier Science Publishers BV, 1986, pp. 154-178.
Herold et al., "A Versatile and Stereocontrolled Synthesis of Hydroxyethylene Dipeptide Isosteres," J. Org. Chem., vol. 54 (1989), pp. 1178-1185.
Bradbury et al., "An Efficient Synthesis of the .gamma.-Lactone Corresponding to a Hydroxyethylene Dipeptide Isostere Using Stereoselective Bromolactonisation of a Chiral Acyloxazolidinone," Tetrahedron Letters, vol. 30, No. 29 (1989), pp. 3845-3848.
Bradbury et al., "1,2,4-Triazolo[4,3-a]pyrazine Derivatives with Human Renin Inhibitory Activity," J. Med. Chem., vol. 33 (1990), pp. 2335-2342.
Wuts et al., "Synthesis of the Hydroxyethylene Isostere of Leu-Val," J. Org. Chem., vol. 57 (1992), pp. 6696-6700.
Jones et al., "A Short Stereocontrolled Synthesis of Hydroxyethylene Dipeptide Isosteres," J. Org. Chem., vol. 58 (1993), pp. 2286-2290.
Pegorier et al., "A General Stereocontrolled Synthesis of Hydroxyethylene Dipeptide Isosteres," Tetrahedron Letters, vol. 36, No. 16 (1995), pp. 2753-2756.
Dondoni et al., "Thiazole-Based Stereoselective Routes to Leucine and Phenylalanine Hydroxyethylene Dipeptide Isostere Inhibitors of Renin and HIV-1 Aspartic Protease," J. Org. Chem., vol. 60 (1995), pp. 7927-7933.
Weislow et al., "New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral Activity," Journal of the National Cancer Institute, vol. 81, No. 8 (1989), pp. 577-586.
L.A. Carpino, "1-Hydroxy-7-Azabenzotriazole. An Efficient Peptide Coupling Additive," Journal of the American Chemical Society, vol. 115, No. 10 (1993), pp. 4397-4398.
J.E. Baldwin, et al., "An Intramolecular Cobalt Cyclisation for the Construction of Substituted Pyrrolidines," Tetrahedron, vol. 48, No. 42 (1992), pp. 9373-9384.
J.J. Willard, et al., "New Method of Removing Xanthate Groups from Carbohydrates. Chemical Structure of Methyl .alpha.-D-Glucopyranoside Monoxanthate," Journal of the American Chemical Society, vol. 82, No. 16 (1960), pp. 4347-4350.
R.M. Freidinger, et al., "Synthesis of 9-Fluorenylmethyloxycarbonyl-Protected N-Alkyl Amino Acids by Reduction of Oxazolidinones," Journal of Organic Chemistry, vol. 48, No. 4 (1983), pp. 77-81.
D.A. Niederer, et al., "Amination with N-Benzyloxycarbonyl-3-Phenyloxaziridine as a Route to Sensitive Chiral .alpha.-Hydrazino Acids: Synthesis of L-Hydrazino Serine," Tetrahedron Letters, vol. 34, No. 43 (1993), pp. 6859-6862.
C.A. Veale, et

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antipicornaviral compounds compositions containing them and meth does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antipicornaviral compounds compositions containing them and meth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antipicornaviral compounds compositions containing them and meth will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-938004

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.