Antiphlogistic analgesic plaster

Details Antiphlogistic analgesic plaster Antiphlogistic analgesic plaster

1994-03-21

1995-12-26

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424485, 424486, 424448, 602 48, 602 54, 428355, A61F 1302, A61L 1524, A61L 1558, A61L 1542

Patent

active

054785677

DESCRIPTION:

BRIEF SUMMARY
TECHNICAL FIELD

This invention relates to a novel antiphlogistic analgesic plaster for therapeutic use which contains at least one nonsteroidal antiphlogistic analgesic drug selected from among ketoprofen, flurbiprofen, loxoprofen, ketorolac and esters or salts thereof and a rosin ester derivative and l-menthol employed as a solvent and has a polyester cloth employed as a backing.


BACKGROUND ART

Attempts have been widely made to apply so-called tapes comprising a nonsteroidal antiphlogistic (or anti-inflammatory) analgesic drug contained in an oily pressure-sensitive adhesive to therapeutic uses. For example, Japanese Patent Laid-Open Gazette No. 227819/1984 has disclosed an attempt to administer a nonsteroidal antiphlogistic analgesic drug which is contained in an acrylic pressure-sensitive adhesive located on a composite backing consisting of a nonwoven fabric and a film. Further, Japanese Patent Laid-Open Gazette No. 139615/1985 has disclosed an attempt to administer ketoprofen which is contained in a pressure-sensitive adhesive comprising polyisobutylene/paraffin/rosin-modified glycerol ester, to allow the ketoprofen to be percutaneously absorbed. Japanese Patent Laid-Open Gazette No. 227524/1988 has disclosed an attempt to administer flurbiprofen together with an oily base. Furthermore, Japanese Patent Laid-Open No. 40420/1989 has disclosed an attempt to administer, together with an oily base, a nonsteroidal antiphlogistic analgesic drug having a carboxyl group.
However, none of these attempts are satisfactory in drug-release characteristics or percutaneous absorption characteristics. It is therefore urgently required to develop a preparation having superior properties.
It is an object of the present invention to provide an antiphlogistic analgesic plaster having characteristics remarkably improved in the following points: and releasability of a nonsteroidal antiphlogistic analgesic drug in a base), a nonsteroidal antiphlogistic analgesic drug), plastering (utilization of a safe base and search for not adhesion but stickiness through the establishment of an appropriate compositional ratio of the base), and stretchability as to enable the stickiness to a flexional part).


SUMMARY OF THE INVENTION

In order to achieve the above-mentioned object, the present inventors have conducted extensive studies on ketoprofen, flurbiprofen, loxoprofen and ketorolac, which are nonsteroidal antiphlogistic analgesic drugs having carboxylic acid, and ester derivatives or salts thereof. As a result of their studies, they have successfully completed the development of an antiphlogistic analgesic plaster according to the present invention which is characterized by comprising the following ingredients (a) to (e) as essential ingredients. Accordingly, the antiphlogistic analgesic plaster of this invention comprises as essential ingredients: among ketoprofen, flurbiprofen, loxoprofen, ketorolac and ester derivatives or salts thereof; l-menthol;
As the backing to be used in the present invention, polyester cloths exerting no effect on the release of the nonsteroidal antiphlogistic analgesic drug are selected. Among others, a cloth made from PET (polyethylene terephthalate) or PBT (polybutylene terephthalate) is preferable. In order to achieve excellent release of the nonsteroidal antiphlogistic analgesic drug, it is essentially required that the backing undergoes no interaction with the nonsteroidal antiphlogistic analgesic drug, namely, never adsorbs the drug. As the result of the examination of backings of various compositions, the present inventors have found out that PET and PBT are the most suitable polymer composition for the backing. By using a backing comprising PET or PBT, excellent release can be achieved without causing any adsorption of the drug on the backing.
The antiphlogistic analgesic plaster of the present invention is endowed with such a stretchability having an average stress of 0.3 kg/cm or below when it is 50% elongated in the longitudinal or lateral direction as to enable the antiphlogistic analgesi

REFERENCES:
patent: 4455146 (1984-06-01), Noda et al.
patent: 4661104 (1987-04-01), von Bittera et al.
patent: 4814168 (1989-03-01), Sablotsky et al.
patent: 5296235 (1994-03-01), Sawayanagi et al.

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