Antiphlogistic, analgesic, antipyretic injection preparation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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A61K 31135

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active

055546501

ABSTRACT:
An antiphlogistic, analgesic, antipyretic parenteral preparation is disclosed comprising diclofenac, its salt, or both, a surfactant, cosurfactant, water, having a pH of 3-10, and optionally comprising an oily component, that can exhibit sustained therapeutic levels of diclofenac in plasma.

REFERENCES:
patent: 5208035 (1993-05-01), Okuyama et al.
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L otroth et al., Liquid Crystalline Phases as Delivery Systems for Drugs II. In-Vitro, Department of Physical Pharmacy, AB Hassle, M olndal, Sweden (1988), Process Intern Symp. Rel. Biol. Mater 15.
Ericsson et al., Liquid Crystalline Phases as Delivery Systems for Drugs II. In-Vivo, S-200 62 Malm o, Sweden (1988), Process Intern Symp. Rel. Biol. Mater 15.
Larsson, Cubic Lipid--Water Phases: Structures and Biomembrane Aspects, J. Phys. Chem. (1989), vol. 93, pp. 7304-7314.
Engstr om, Drug Delivery From Cubic and other Lipid-Water Phases, Cubic Lipid-Water Phases, 1991.
Hyde et al., A cubic structure consisting of a lipid bilayer forming an infinite periodic minimum surface of the gyroid type in the glycerolmonooleat-water system, Department of Food Technology, University of Lund, Lund, Sweden (1984), Zeitschrift for Kristallographie 163, 213-219.
Michio et al., Solubilization of vitamin K and oils in water by surfactants containing fatty acid triglyceryl esters--Chemical Abstract--105:214097x, 1987.
Gautier et al., Stable microemulsions containing bithionol--Chemical Abstract--111:45291x, 1988.

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