Drug – bio-affecting and body treating compositions – Anti-perspirants or perspiration deodorants
Patent
1996-05-07
1998-12-01
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Anti-perspirants or perspiration deodorants
424 7802, 424 7808, 424 7817, 424400, 424401, A61K 732, A61K 3174, A61K 700
Patent
active
058434135
DESCRIPTION:
BRIEF SUMMARY
This invention relates to antiperspirants and, more particularly, to a new antiperspirant product.
Antiperspirants are sold in three formulations, namely as aerosols (aluminium chlorhydroxide complex (ACH)), and in the zirconium form as roll-ons and wax-like sticks. Mixing the active antiperspirant with other substances in these formulations, particularly in roll-ons and sticks, can cause a significant reduction in the efficacy of the product in reducing the production of perspiration. Whilst aerosols do not suffer so much from this problem, there is currently a move away from aerosol type formulations for environmental reasons.
We have now devised a new antiperspirant product which is not an aerosol and which does not necessitate the use of materials which significantly reduce the efficacy of the antiperspirant material therein.
In accordance with a first aspect of the present invention, the antiperspirant product comprises a water-insoluble, porous, cross-linked polymeric matrix having an antiperspirant homogeneously distributed therein in interconnecting pores thereof, the product being in the form of a hard shape from which the antiperspirant can be released by water leaching with zero order release without change in the pore geometry.
The polymeric matrix is water-insoluble and serves to hold the antiperspirant therein until it is required. There are a lot of suitable materials from which the matrix may be made, for example polyurethanes, epoxy resins, polyolefins, polystyrene, polyvinyl chloride, phenol formaldehydes, silicones, poly(meth)acrylates, polyamides and poly(meth)acrylamides. We prefer to use cross-linked polymers made from ethylenically unsaturated monomers, for example cross-linked polyacrylates or polymethacrylates, such as poly(bisphenol A) propyl dimethacrylate, ethylene glycol dimethacrylate, triethylene glycol dimethacrylate or tetraethylene glycol dimethacrylate.
The product is made by mixing the matrix-forming materials with the antiperspirant, and then polymerising and/or cross-linking. According to a second aspect of the invention, there is provided a method of making a product of the invention, which method comprises forming a mixture of an antiperspirant and matrix-forming materials; and polymerising and/or cross-linking the matric-forming materials to form a water-insoluble, porous, cross-linked polymeric matrix with the antiperspirant homogeneously distributed therein in interconnecting pores thereof.
The antiperspirant is substantially homogeneously distributed throughout the matrix. The relative amounts of ACH and matrix-forming materials can vary widely. For example, on a weight basis, the product can comprise up to about 99% ACH, or up to about 95% matrix-forming material. More usually, the amount of ACH is from 30 to 80%, most preferably from 60 to 70%. The amount of polymeric matrix is usually from 20 to 60%, most preferably from about 20 to 35%.
The antiperspirant must be phase-separated from the matrix-forming materials so that it forms the pores in the final matrix. Normally, solid antiperspirant is used but liquid solutions can be employed. When an aqueous solution is used, it will dry out to leave a solid within, for example, 24 hours.
The precise nature of the active antiperspirant used in the products of this invention is not critical. Any material with antiperspirant properties can be used including, of course, those presently in common use in the art. Since it is not necessary in the present invention to use any significant amount of other materials, the efficacy of the antiperspirant as applied to the skin can be comparable with fresh "hot room" solutions, i.e. up to 80% sweat reduction or more can be achieved compared with the 50% or less associated with currently marketed forms of antiperspirant.
We have found that in use of the products of the invention, the active antiperspirant displays bactericidal properties.
The product can be made in any desired shape. A simple stick or other shape can be provided, for use with or without a holder. However, other sha
REFERENCES:
patent: 3317394 (1967-05-01), Fryklof et al.
patent: 3682848 (1972-08-01), Virnelson
patent: 4723860 (1988-02-01), Giblin et al.
Baines Frederick Charles
Causton Brian Edward
Dodson Shelley A.
The Gillette Company
Williams Stephan P.
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