Antipathogenic benzamide compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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C544S141000, C544S139000, C544S140000, C544S134000, C544S137000, C544S138000

Reexamination Certificate

active

07348427

ABSTRACT:
Antipathogenic benzamide compounds having the formulawherein at least one of the R1groups is F, Cl, CN or CF3and R2, R3, Y, Z, m, and n are as defined herein.

REFERENCES:
patent: 5049579 (1991-09-01), Lazzari et al.
patent: 5472976 (1995-12-01), Animati et al.
patent: 5670534 (1997-09-01), Animati et al.
patent: 5698674 (1997-12-01), Bruice et al.
patent: 5753629 (1998-05-01), Beria et al.
patent: 5808087 (1998-09-01), Matsunaga et al.
patent: 5821258 (1998-10-01), Matsunaga et al.
patent: 5852011 (1998-12-01), Matsunaga et al.
patent: 5998140 (1999-12-01), Dervan et al.
patent: 6090947 (2000-07-01), Dervan et al.
patent: 6143901 (2000-11-01), Dervan
patent: 6177408 (2001-01-01), Cozzi et al.
patent: 6555693 (2003-04-01), Ge et al.
patent: 2003/0083268 (2003-05-01), Burli et al.
patent: 2003/0199516 (2003-10-01), Moser et al.
patent: 8-269008 (1996-10-01), None
patent: WO 93/13739 (1993-07-01), None
patent: WO 94/20463 (1994-09-01), None
patent: WO 97/03957 (1997-02-01), None
patent: WO 97/28123 (1997-08-01), None
patent: WO 98/21202 (1998-05-01), None
patent: WO 98/35702 (1998-08-01), None
patent: WO 98/37066 (1998-08-01), None
patent: WO 98/37067 (1998-08-01), None
patent: WO 98/37087 (1998-08-01), None
patent: WO 98/45284 (1998-10-01), None
patent: WO 98/49142 (1998-11-01), None
patent: WO 98/50582 (1998-11-01), None
patent: WO 98/52614 (1998-11-01), None
patent: WO 99/50266 (1999-10-01), None
patent: WO 99/64413 (1999-12-01), None
patent: WO 00/06541 (2000-02-01), None
patent: WO 00/06542 (2000-02-01), None
patent: WO 00/15209 (2000-03-01), None
patent: WO 00/15773 (2000-03-01), None
patent: WO 02/00650 (2002-01-01), None
U.S. Appl. No. 60/322,704, filed Sep. 13, 2001, Moser et al.
Acamone et al., 1986, “Synthesis, DNA binding and antiviral activity of distamycin analogues containing different heterocyclic moleties,”Anti-Cancer Drug Design1:235-244.
Bailly and Chaires, 1998, “Sequence-specific DNA minor groove binders. Design and synthesis of netropsin and distamycin analogues,”Bioconjugate Chemistry9(5):513-538.
Boger et al., 2000, “Total synthesis of distamycin A and 2640 analogues: A solution-phase combinatorial approach to the discovery of new, bioactive DNA binding agents and development of a rapid, high-throughput screen for determining relative DNA binding affinity or DNA binding sequence selectivity,”J. Am. Chem. Soc.122:6382-6394.
Ellervik et al., 2000, “Hydroxybenzamide/pyrrole pair distinguishes T-A from A-T base pairs in the minor groove of DNA,”J. Am. Chem. Soc.122:9354-9360.
Floreancig et al., 2000, “Recognition of the minor groove of DNA by hairpin polyamides containing α-substituted-β-amino acids,”J. Am. Chem. Soc.122:6342-6350.
Kelly et al., 1996, “Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif,”Proc. Natl. Acad. Sci. U.S.A.93:6981-6985.
Khalaf et al., 2000, “The synthesis of some head to head linked DNA minor groove binders,”Tetrahedron56:5225-5239.
Machon and Ryng, 1981, “Synthesis and biological properties of 5-benzoylamino-3-methyl-4-isoxazolocarboxylic acid derivatives,”Archivum Immunologiae et Therapiae Experimentalis29:813-821.
Mrksich et al., 1994, “Hairpin peptide motif. A new class of oligopeptides for sequence-specific recognition in the minor groove of double-helical DNA,”J. Am. Chem. Soc.116:7983-7988.
Neidle, S., 2001, “DNA minor-groove recognition by small molecules,”Natl. Prod. Rep.18:291-309.
Nielsen, P., 1991, “Sequence-selective DNA recognition by synthetic ligands,”Bioconjugate Chemistry2(1):1-12.
Plescia et al., 1994, “3α-hydroxysteroid dehydrogenase inhibitory activity of some N(3)-(1-R-4-carboxypyrazol-5-yl)-1,2,3-benzotriazin-4(3H)-one and quinazolin-4(3H)-one acids,”II Farmaco47(7,8):505-507.
Rao et al., 1988, “Interaction of synthetic analogues of distamycin and netropsin with nucleic acids. Does curvature of ligand play a role in distamycin-DNA interactions?”Biochemistry27(8):3018-3024.
Trauger et al., 1996, “Recognition of DNA by designed ligands at subnanomolar concentrations,”Nature382:559-561.
Wade et al., 1992, “Design of peptides that bind in the minor groove of DNA at 5′-(A,T)G(A,T)C(A,T)-3′ sequences by a dimeric side-by-side motif,”J. Am. Chem. Soc.114:8784-8794.
White et al., 1997, “On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides,”Chemistry&Biology4:569-578.
White et al., 1998, “Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands,”Nature391:468-471.

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